Cargando…

Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells

Renal cell carcinoma has emerged as one of the leading causes of cancer-related deaths in the USA. Here, we examined the anticancer profile of oxindole derivatives (SH-859) in human renal cancer cells. Targeting 786-O cells by SH-859 inhibited cell growth and affected the protein kinase B/mechanisti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dey, Prasanta, Kundu, Amit, Han, Sang Hoon, Kim, Kyeong-Seok, Park, Jae Hyeon, Yoon, Sungpil, Kim, In Su, Kim, Hyung Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565513/ https://www.ncbi.nlm.nih.gov/pubmed/32878322 http://dx.doi.org/10.3390/biom10091260

Ejemplares similares

Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma
por: Dey, Prasanta, et al.
Publicado: (2019)

EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats
por: Kundu, Amit, et al.
Publicado: (2020)

Low-Dose Crizotinib, a Tyrosine Kinase Inhibitor, Highly and Specifically Sensitizes P-Glycoprotein-Overexpressing Chemoresistant Cancer Cells Through Induction of Late Apoptosis in vivo and in vitro
por: Kim, Kyeong Seok, et al.
Publicado: (2020)

Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents
por: Al-Majid, Abdullah Mohammed, et al.
Publicado: (2021)

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Contribution of Cancer-Targeting Drugs toward Faster Clinical Application
por: Yoon, Sungpil, et al.
Publicado: (2022)

First-Line Combination Treatment with Low-Dose Bipolar Drugs for ABCB1-Overexpressing Drug-Resistant Cancer Populations
por: Yoon, Sungpil, et al.
Publicado: (2023)

Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats
por: Sachan, Richa, et al.
Publicado: (2020)

Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/(C) Mice
por: Kundu, Amit, et al.
Publicado: (2023)

JAK2 Inhibitor, Fedratinib, Inhibits P-gp Activity and Co-Treatment Induces Cytotoxicity in Antimitotic Drug-Treated P-gp Overexpressing Resistant KBV20C Cancer Cells
por: Oh, Yunmoon, et al.
Publicado: (2022)

Terconazole, an Azole Antifungal Drug, Increases Cytotoxicity in Antimitotic Drug-Treated Resistant Cancer Cells with Substrate-Specific P-gp Inhibitory Activity
por: Lee, Ji Sun, et al.
Publicado: (2022)

Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding
por: Park, Eun Young, et al.
Publicado: (2016)

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)
por: Dey, Prasanta, et al.
Publicado: (2020)

Molineria recurvata Ameliorates Streptozotocin-Induced Diabetic Nephropathy through Antioxidant and Anti-Inflammatory Pathways
por: Dey, Prasanta, et al.
Publicado: (2022)

Characterization of biological responses of colorectal cancer cells to anticancer regimens
por: Roh, Seon Ae, et al.
Publicado: (2012)

Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells
por: Lee, Su Hyun, et al.
Publicado: (2022)

Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents
por: Chen, Gaozhi, et al.
Publicado: (2014)

Low-Dose Rifabutin Increases Cytotoxicity in Antimitotic-Drug-Treated Resistant Cancer Cells by Exhibiting Strong P-gp-Inhibitory Activity
por: Lee, Ji Sun, et al.
Publicado: (2022)

Novel SIRT1 inhibitor 15-deoxy-Δ(12,14)-prostaglandin J(2) and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells
por: Tae, In Hwan, et al.
Publicado: (2018)

Non-Palladium-Catalyzed Approach to the Synthesis of (E)-3-(1,3-Diarylallylidene)Oxindoles
por: Koo, Jahyun, et al.
Publicado: (2022)

Lower Salinomycin Concentration Increases Apoptotic Detachment in High-Density Cancer Cells
por: Kim, Ju-Hwa, et al.
Publicado: (2012)

Design, synthesis, and discovery of novel oxindoles bearing 3-heterocycles as species-specific and combinatorial agents in eradicating Staphylococcus species
por: Shin, Jonghoon, et al.
Publicado: (2019)

Synthesis of TMPA Derivatives through Sequential Ir(III)-Catalyzed C–H Alkylation and Their Antidiabetic Evaluation
por: Lee, Suk Hun, et al.
Publicado: (2018)

Identification of potential biological targets of oxindole scaffolds via in silico repositioning strategies
por: Tinivella, Annachiara, et al.
Publicado: (2022)

3-Arylidene-2-oxindoles as GSK3β inhibitors and anti-thrombotic agents
por: Babkov, Denis, et al.
Publicado: (2023)

Low Amount of Salinomycin Greatly Increases Akt Activation, but Reduces Activated p70S6K Levels
por: Kim, Ju-Hwa, et al.
Publicado: (2013)

Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents
por: Ismail, Rania S. M., et al.
Publicado: (2023)

Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective in vitro Anticancer Effects
por: Abo-Salem, Heba M., et al.
Publicado: (2020)

Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives
por: Dey, Prasanta, et al.
Publicado: (2019)

Identification of 3-Oxindole Derivatives as Small Molecule HIV-1 Inhibitors Targeting Tat-Mediated Viral Transcription
por: Kim, Dong-Eun, et al.
Publicado: (2022)

Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma
por: Kwak, Tae Won, et al.
Publicado: (2015)

Rauniticine-allo-oxindole B methanol monosolvate
por: Salim, Fatimah, et al.
Publicado: (2011)

Synthesis, Antimicrobial and Antioxidant Activity of Some Oxindoles
por: Rindhe, S. S., et al.
Publicado: (2011)

Electrochemical Umpolung C–H Functionalization of Oxindoles
por: Pastor, Miryam, et al.
Publicado: (2021)

Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats
por: Shin, Jun-Kyu, et al.
Publicado: (2020)

Regio- and stereoselective synthesis of spiropyrrolidine-oxindole and bis-spiropyrrolizidine-oxindole grafted macrocycles through [3 + 2] cycloaddition of azomethine ylides
por: Prabhakaran, Perumal, et al.
Publicado: (2020)

Ring-opening cyclization of activated spiro-aziridine oxindoles with heteroarenes: a facile synthetic approach to spiro-oxindole-fused pyrroloindolines
por: Bhandari, Sonal, et al.
Publicado: (2020)

Applications of Cancer Cell-Specific Aptamers in Targeted Delivery of Anticancer Therapeutic Agents
por: Kim, Minhee, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors
por: Lin, Jing, et al.
Publicado: (2022)

Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity
por: Sharma, Richa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d7riht2rup0gtnbou54ui6iglo