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Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study

We investigated the association between post-rewarming fever (PRF) and 6-month neurologic outcomes in cardiac arrest survivors. This was a multicenter study based on a registry of comatose adult (≥18 years) out-of-hospital cardiac arrest (OHCA) survivors who underwent targeted temperature management...

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Autores principales: Lee, Hyoung Youn, Lee, Dong Hun, Lee, Byung Kook, Jeung, Kyung Woon, Jung, Yong Hun, Choi, Seung Phil, Park, Jung Soo, Lee, Jae Hoon, Han, Kap Su, Min, Yong Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565524/
https://www.ncbi.nlm.nih.gov/pubmed/32927857
http://dx.doi.org/10.3390/jcm9092927
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author Lee, Hyoung Youn
Lee, Dong Hun
Lee, Byung Kook
Jeung, Kyung Woon
Jung, Yong Hun
Choi, Seung Phil
Park, Jung Soo
Lee, Jae Hoon
Han, Kap Su
Min, Yong Il
author_facet Lee, Hyoung Youn
Lee, Dong Hun
Lee, Byung Kook
Jeung, Kyung Woon
Jung, Yong Hun
Choi, Seung Phil
Park, Jung Soo
Lee, Jae Hoon
Han, Kap Su
Min, Yong Il
author_sort Lee, Hyoung Youn
collection PubMed
description We investigated the association between post-rewarming fever (PRF) and 6-month neurologic outcomes in cardiac arrest survivors. This was a multicenter study based on a registry of comatose adult (≥18 years) out-of-hospital cardiac arrest (OHCA) survivors who underwent targeted temperature management between October 2015 to December 2018. PRF was defined as peak temperature ≥ 38.0 °C within 72 h after completion of rewarming, and PRF timing was categorized as within 24, 24–48, and 48–72 h epochs. The primary outcome was neurologic outcomes at six months after cardiac arrest. Unfavorable neurologic outcome was defined as cerebral performance categories three to five. A total of 1031 patients were included, and 642 (62.3%) had unfavorable neurologic outcomes. PRF developed in 389 (37.7%) patients in 72 h after rewarming: within 24 h in 150 (38.6%), in 24–48 h in 155 (39.8%), and in 48–72 h in 84 (21.6%). PRF was associated with improved neurologic outcomes (odds ratio (OR), 0.633; 95% confidence interval (CI), 0.416–0.963). PRF within 24 h (OR, 0.355; 95% CI, 0.191–0.659), but not in 24–48 h or 48–72 h, was associated with unfavorable neurologic outcomes. Early PRF within 24 h after rewarming was associated with favorable neurologic outcomes.
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spelling pubmed-75655242020-10-26 Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study Lee, Hyoung Youn Lee, Dong Hun Lee, Byung Kook Jeung, Kyung Woon Jung, Yong Hun Choi, Seung Phil Park, Jung Soo Lee, Jae Hoon Han, Kap Su Min, Yong Il J Clin Med Article We investigated the association between post-rewarming fever (PRF) and 6-month neurologic outcomes in cardiac arrest survivors. This was a multicenter study based on a registry of comatose adult (≥18 years) out-of-hospital cardiac arrest (OHCA) survivors who underwent targeted temperature management between October 2015 to December 2018. PRF was defined as peak temperature ≥ 38.0 °C within 72 h after completion of rewarming, and PRF timing was categorized as within 24, 24–48, and 48–72 h epochs. The primary outcome was neurologic outcomes at six months after cardiac arrest. Unfavorable neurologic outcome was defined as cerebral performance categories three to five. A total of 1031 patients were included, and 642 (62.3%) had unfavorable neurologic outcomes. PRF developed in 389 (37.7%) patients in 72 h after rewarming: within 24 h in 150 (38.6%), in 24–48 h in 155 (39.8%), and in 48–72 h in 84 (21.6%). PRF was associated with improved neurologic outcomes (odds ratio (OR), 0.633; 95% confidence interval (CI), 0.416–0.963). PRF within 24 h (OR, 0.355; 95% CI, 0.191–0.659), but not in 24–48 h or 48–72 h, was associated with unfavorable neurologic outcomes. Early PRF within 24 h after rewarming was associated with favorable neurologic outcomes. MDPI 2020-09-10 /pmc/articles/PMC7565524/ /pubmed/32927857 http://dx.doi.org/10.3390/jcm9092927 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Hyoung Youn
Lee, Dong Hun
Lee, Byung Kook
Jeung, Kyung Woon
Jung, Yong Hun
Choi, Seung Phil
Park, Jung Soo
Lee, Jae Hoon
Han, Kap Su
Min, Yong Il
Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study
title Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study
title_full Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study
title_fullStr Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study
title_full_unstemmed Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study
title_short Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study
title_sort early post-rewarming fever is associated with favorable 6-month neurologic outcomes in patients with out-of-hospital cardiac arrest: a multicenter registry study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565524/
https://www.ncbi.nlm.nih.gov/pubmed/32927857
http://dx.doi.org/10.3390/jcm9092927
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