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Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis
Background: The incidence of inflammatory bowel diseases (IBD) and its significance in kidney transplant recipients is not well established. We conducted this systematic review and meta-analysis to assess the incidence of and complications from IBD in adult kidney transplant recipients. Methods: Eli...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565568/ https://www.ncbi.nlm.nih.gov/pubmed/32947774 http://dx.doi.org/10.3390/medsci8030039 |
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author | Hansrivijit, Panupong Puthenpura, Max M. Thongprayoon, Charat Brar, Himmat S. Bathini, Tarun Kovvuru, Karthik Kanduri, Swetha R. Wijarnpreecha, Karn Cheungpasitporn, Wisit |
author_facet | Hansrivijit, Panupong Puthenpura, Max M. Thongprayoon, Charat Brar, Himmat S. Bathini, Tarun Kovvuru, Karthik Kanduri, Swetha R. Wijarnpreecha, Karn Cheungpasitporn, Wisit |
author_sort | Hansrivijit, Panupong |
collection | PubMed |
description | Background: The incidence of inflammatory bowel diseases (IBD) and its significance in kidney transplant recipients is not well established. We conducted this systematic review and meta-analysis to assess the incidence of and complications from IBD in adult kidney transplant recipients. Methods: Eligible articles were searched through Ovid MEDLINE, EMBASE, and the Cochrane Library from inception through April 2020. The inclusion criteria were adult kidney transplant patients with reported IBD. Effect estimates from the individual studies were extracted and combined using the fixed-effects model when I(2) ≤ 50% and random-effects model when I(2) > 50%. Results: of 641 citations, a total of seven studies (n = 212) were included in the systematic review. The mean age was 46.2 +/− 6.9 years and up to 51.1% were male. The mean duration of follow-up was 57.8 +/− 16.8 months. The pooled incidence of recurrent IBD was 27.6% (95% CI, 17.7–40.5%; I(2) 0%) while the pooled incidence of de novo IBD was 18.8% (95% CI, 10.7–31.0%; I(2) 61.3%). The pooled incidence of post-transplant IBD was similar across subgroup analyses. Meta-regression analyses showed no association between the incidence of IBD and age, male sex, and follow-up duration. For post-transplant complications, the pooled incidence of post-transplant infection was 4.7% (95% CI, 0.5–33.3%; I(2) 73.7%). The pooled incidence of graft rejection and re-transplantation in IBD patients was 31.4% (95% CI, 14.1–56.1%; I(2) 76.9%) and 30.4% (95% CI, 22.6–39.5%; I(2) 0%). Conclusion: Recurrent and de novo IBD is common among kidney transplant recipients and may result in adverse outcomes. |
format | Online Article Text |
id | pubmed-7565568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75655682020-10-26 Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis Hansrivijit, Panupong Puthenpura, Max M. Thongprayoon, Charat Brar, Himmat S. Bathini, Tarun Kovvuru, Karthik Kanduri, Swetha R. Wijarnpreecha, Karn Cheungpasitporn, Wisit Med Sci (Basel) Article Background: The incidence of inflammatory bowel diseases (IBD) and its significance in kidney transplant recipients is not well established. We conducted this systematic review and meta-analysis to assess the incidence of and complications from IBD in adult kidney transplant recipients. Methods: Eligible articles were searched through Ovid MEDLINE, EMBASE, and the Cochrane Library from inception through April 2020. The inclusion criteria were adult kidney transplant patients with reported IBD. Effect estimates from the individual studies were extracted and combined using the fixed-effects model when I(2) ≤ 50% and random-effects model when I(2) > 50%. Results: of 641 citations, a total of seven studies (n = 212) were included in the systematic review. The mean age was 46.2 +/− 6.9 years and up to 51.1% were male. The mean duration of follow-up was 57.8 +/− 16.8 months. The pooled incidence of recurrent IBD was 27.6% (95% CI, 17.7–40.5%; I(2) 0%) while the pooled incidence of de novo IBD was 18.8% (95% CI, 10.7–31.0%; I(2) 61.3%). The pooled incidence of post-transplant IBD was similar across subgroup analyses. Meta-regression analyses showed no association between the incidence of IBD and age, male sex, and follow-up duration. For post-transplant complications, the pooled incidence of post-transplant infection was 4.7% (95% CI, 0.5–33.3%; I(2) 73.7%). The pooled incidence of graft rejection and re-transplantation in IBD patients was 31.4% (95% CI, 14.1–56.1%; I(2) 76.9%) and 30.4% (95% CI, 22.6–39.5%; I(2) 0%). Conclusion: Recurrent and de novo IBD is common among kidney transplant recipients and may result in adverse outcomes. MDPI 2020-09-16 /pmc/articles/PMC7565568/ /pubmed/32947774 http://dx.doi.org/10.3390/medsci8030039 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hansrivijit, Panupong Puthenpura, Max M. Thongprayoon, Charat Brar, Himmat S. Bathini, Tarun Kovvuru, Karthik Kanduri, Swetha R. Wijarnpreecha, Karn Cheungpasitporn, Wisit Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis |
title | Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis |
title_full | Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis |
title_fullStr | Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis |
title_full_unstemmed | Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis |
title_short | Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis |
title_sort | incidence and impacts of inflammatory bowel diseases among kidney transplant recipients: a meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565568/ https://www.ncbi.nlm.nih.gov/pubmed/32947774 http://dx.doi.org/10.3390/medsci8030039 |
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