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A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD

Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linka...

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Autores principales: Hirano, Tsunahiko, Doi, Keiko, Matsunaga, Kazuto, Takahashi, Shun, Donishi, Tomohiro, Suga, Kazuyoshi, Oishi, Keiji, Yasuda, Kasumi, Mimura, Yusuke, Harada, Misa, Suizu, Sumiteru, Murakawa, Keita, Chikumoto, Ayumi, Ohteru, Yuichi, Matsuda, Kazuki, Uehara, Sho, Hamada, Kazuki, Ohata, Shuichiro, Murata, Yoriyuki, Yamaji, Yoshikazu, Asami-Noyama, Maki, Edakuni, Nobutaka, Kakugawa, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565594/
https://www.ncbi.nlm.nih.gov/pubmed/32847145
http://dx.doi.org/10.3390/jcm9092737
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author Hirano, Tsunahiko
Doi, Keiko
Matsunaga, Kazuto
Takahashi, Shun
Donishi, Tomohiro
Suga, Kazuyoshi
Oishi, Keiji
Yasuda, Kasumi
Mimura, Yusuke
Harada, Misa
Suizu, Sumiteru
Murakawa, Keita
Chikumoto, Ayumi
Ohteru, Yuichi
Matsuda, Kazuki
Uehara, Sho
Hamada, Kazuki
Ohata, Shuichiro
Murata, Yoriyuki
Yamaji, Yoshikazu
Asami-Noyama, Maki
Edakuni, Nobutaka
Kakugawa, Tomoyuki
author_facet Hirano, Tsunahiko
Doi, Keiko
Matsunaga, Kazuto
Takahashi, Shun
Donishi, Tomohiro
Suga, Kazuyoshi
Oishi, Keiji
Yasuda, Kasumi
Mimura, Yusuke
Harada, Misa
Suizu, Sumiteru
Murakawa, Keita
Chikumoto, Ayumi
Ohteru, Yuichi
Matsuda, Kazuki
Uehara, Sho
Hamada, Kazuki
Ohata, Shuichiro
Murata, Yoriyuki
Yamaji, Yoshikazu
Asami-Noyama, Maki
Edakuni, Nobutaka
Kakugawa, Tomoyuki
author_sort Hirano, Tsunahiko
collection PubMed
description Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = −0.43, p < 0.001) and MoCA-J (ρ = −0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.
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spelling pubmed-75655942020-10-26 A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD Hirano, Tsunahiko Doi, Keiko Matsunaga, Kazuto Takahashi, Shun Donishi, Tomohiro Suga, Kazuyoshi Oishi, Keiji Yasuda, Kasumi Mimura, Yusuke Harada, Misa Suizu, Sumiteru Murakawa, Keita Chikumoto, Ayumi Ohteru, Yuichi Matsuda, Kazuki Uehara, Sho Hamada, Kazuki Ohata, Shuichiro Murata, Yoriyuki Yamaji, Yoshikazu Asami-Noyama, Maki Edakuni, Nobutaka Kakugawa, Tomoyuki J Clin Med Article Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = −0.43, p < 0.001) and MoCA-J (ρ = −0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients. MDPI 2020-08-24 /pmc/articles/PMC7565594/ /pubmed/32847145 http://dx.doi.org/10.3390/jcm9092737 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hirano, Tsunahiko
Doi, Keiko
Matsunaga, Kazuto
Takahashi, Shun
Donishi, Tomohiro
Suga, Kazuyoshi
Oishi, Keiji
Yasuda, Kasumi
Mimura, Yusuke
Harada, Misa
Suizu, Sumiteru
Murakawa, Keita
Chikumoto, Ayumi
Ohteru, Yuichi
Matsuda, Kazuki
Uehara, Sho
Hamada, Kazuki
Ohata, Shuichiro
Murata, Yoriyuki
Yamaji, Yoshikazu
Asami-Noyama, Maki
Edakuni, Nobutaka
Kakugawa, Tomoyuki
A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
title A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
title_full A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
title_fullStr A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
title_full_unstemmed A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
title_short A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
title_sort novel role of growth differentiation factor (gdf)-15 in overlap with sedentary lifestyle and cognitive risk in copd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565594/
https://www.ncbi.nlm.nih.gov/pubmed/32847145
http://dx.doi.org/10.3390/jcm9092737
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