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A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD
Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linka...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565594/ https://www.ncbi.nlm.nih.gov/pubmed/32847145 http://dx.doi.org/10.3390/jcm9092737 |
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author | Hirano, Tsunahiko Doi, Keiko Matsunaga, Kazuto Takahashi, Shun Donishi, Tomohiro Suga, Kazuyoshi Oishi, Keiji Yasuda, Kasumi Mimura, Yusuke Harada, Misa Suizu, Sumiteru Murakawa, Keita Chikumoto, Ayumi Ohteru, Yuichi Matsuda, Kazuki Uehara, Sho Hamada, Kazuki Ohata, Shuichiro Murata, Yoriyuki Yamaji, Yoshikazu Asami-Noyama, Maki Edakuni, Nobutaka Kakugawa, Tomoyuki |
author_facet | Hirano, Tsunahiko Doi, Keiko Matsunaga, Kazuto Takahashi, Shun Donishi, Tomohiro Suga, Kazuyoshi Oishi, Keiji Yasuda, Kasumi Mimura, Yusuke Harada, Misa Suizu, Sumiteru Murakawa, Keita Chikumoto, Ayumi Ohteru, Yuichi Matsuda, Kazuki Uehara, Sho Hamada, Kazuki Ohata, Shuichiro Murata, Yoriyuki Yamaji, Yoshikazu Asami-Noyama, Maki Edakuni, Nobutaka Kakugawa, Tomoyuki |
author_sort | Hirano, Tsunahiko |
collection | PubMed |
description | Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = −0.43, p < 0.001) and MoCA-J (ρ = −0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients. |
format | Online Article Text |
id | pubmed-7565594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75655942020-10-26 A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD Hirano, Tsunahiko Doi, Keiko Matsunaga, Kazuto Takahashi, Shun Donishi, Tomohiro Suga, Kazuyoshi Oishi, Keiji Yasuda, Kasumi Mimura, Yusuke Harada, Misa Suizu, Sumiteru Murakawa, Keita Chikumoto, Ayumi Ohteru, Yuichi Matsuda, Kazuki Uehara, Sho Hamada, Kazuki Ohata, Shuichiro Murata, Yoriyuki Yamaji, Yoshikazu Asami-Noyama, Maki Edakuni, Nobutaka Kakugawa, Tomoyuki J Clin Med Article Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = −0.43, p < 0.001) and MoCA-J (ρ = −0.44, p < 0.001), and Ex and MOCA-J showed a positive correlation (ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients. MDPI 2020-08-24 /pmc/articles/PMC7565594/ /pubmed/32847145 http://dx.doi.org/10.3390/jcm9092737 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hirano, Tsunahiko Doi, Keiko Matsunaga, Kazuto Takahashi, Shun Donishi, Tomohiro Suga, Kazuyoshi Oishi, Keiji Yasuda, Kasumi Mimura, Yusuke Harada, Misa Suizu, Sumiteru Murakawa, Keita Chikumoto, Ayumi Ohteru, Yuichi Matsuda, Kazuki Uehara, Sho Hamada, Kazuki Ohata, Shuichiro Murata, Yoriyuki Yamaji, Yoshikazu Asami-Noyama, Maki Edakuni, Nobutaka Kakugawa, Tomoyuki A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD |
title | A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD |
title_full | A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD |
title_fullStr | A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD |
title_full_unstemmed | A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD |
title_short | A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD |
title_sort | novel role of growth differentiation factor (gdf)-15 in overlap with sedentary lifestyle and cognitive risk in copd |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565594/ https://www.ncbi.nlm.nih.gov/pubmed/32847145 http://dx.doi.org/10.3390/jcm9092737 |
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