A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups

Novel genetic markers like microhaplotypes and compound markers show promising potential in forensic research. Based on previously reported single nucleotide polymorphism (SNP) and insertion/deletion (InDel) polymorphism loci, 29 genetic markers including 22 microhaplotypes and seven compound marker...

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Autores principales: Jin, Xiaoye, Zhang, Xingru, Shen, Chunmei, Liu, Yanfang, Cui, Wei, Chen, Chong, Guo, Yuxin, Zhu, Bofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565596/
https://www.ncbi.nlm.nih.gov/pubmed/32883034
http://dx.doi.org/10.3390/genes11091027
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author Jin, Xiaoye
Zhang, Xingru
Shen, Chunmei
Liu, Yanfang
Cui, Wei
Chen, Chong
Guo, Yuxin
Zhu, Bofeng
author_facet Jin, Xiaoye
Zhang, Xingru
Shen, Chunmei
Liu, Yanfang
Cui, Wei
Chen, Chong
Guo, Yuxin
Zhu, Bofeng
author_sort Jin, Xiaoye
collection PubMed
description Novel genetic markers like microhaplotypes and compound markers show promising potential in forensic research. Based on previously reported single nucleotide polymorphism (SNP) and insertion/deletion (InDel) polymorphism loci, 29 genetic markers including 22 microhaplotypes and seven compound markers were identified. Genetic distributions of the 29 loci in five continental populations, Kazak and Mongolian groups in China were investigated. We found that the expected heterozygosity values of these 29 loci were >0.4 in these populations, indicating these loci were relatively high polymorphisms. Population genetic analyses of five continental populations showed that five loci displayed relatively high genetic variations among these continental populations and could be useful markers for ancestry analysis. In summary, the 29 loci displayed relatively high genetic diversities in continental populations and Chinese two groups and could be informative loci for forensic research.
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spelling pubmed-75655962020-10-26 A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups Jin, Xiaoye Zhang, Xingru Shen, Chunmei Liu, Yanfang Cui, Wei Chen, Chong Guo, Yuxin Zhu, Bofeng Genes (Basel) Article Novel genetic markers like microhaplotypes and compound markers show promising potential in forensic research. Based on previously reported single nucleotide polymorphism (SNP) and insertion/deletion (InDel) polymorphism loci, 29 genetic markers including 22 microhaplotypes and seven compound markers were identified. Genetic distributions of the 29 loci in five continental populations, Kazak and Mongolian groups in China were investigated. We found that the expected heterozygosity values of these 29 loci were >0.4 in these populations, indicating these loci were relatively high polymorphisms. Population genetic analyses of five continental populations showed that five loci displayed relatively high genetic variations among these continental populations and could be useful markers for ancestry analysis. In summary, the 29 loci displayed relatively high genetic diversities in continental populations and Chinese two groups and could be informative loci for forensic research. MDPI 2020-09-01 /pmc/articles/PMC7565596/ /pubmed/32883034 http://dx.doi.org/10.3390/genes11091027 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jin, Xiaoye
Zhang, Xingru
Shen, Chunmei
Liu, Yanfang
Cui, Wei
Chen, Chong
Guo, Yuxin
Zhu, Bofeng
A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups
title A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups
title_full A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups
title_fullStr A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups
title_full_unstemmed A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups
title_short A Highly Polymorphic Panel Consisting of Microhaplotypes and Compound Markers with the NGS and Its Forensic Efficiency Evaluations in Chinese Two Groups
title_sort highly polymorphic panel consisting of microhaplotypes and compound markers with the ngs and its forensic efficiency evaluations in chinese two groups
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565596/
https://www.ncbi.nlm.nih.gov/pubmed/32883034
http://dx.doi.org/10.3390/genes11091027
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