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Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?

Motor abnormalities have been suggested to play a role in most neuropsychiatric disorders, as a potential generic neurodevelopmental vulnerability. However, they still represent a neglected area, with a paucity of empirical studies, especially in pediatric populations. This case-control study aimed...

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Autores principales: Colizzi, Marco, Ciceri, Marco Luigi, Di Gennaro, Gianfranco, Morari, Beatrice, Inglese, Alessandra, Gandolfi, Marialuisa, Smania, Nicola, Zoccante, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565603/
https://www.ncbi.nlm.nih.gov/pubmed/32887253
http://dx.doi.org/10.3390/brainsci10090601
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author Colizzi, Marco
Ciceri, Marco Luigi
Di Gennaro, Gianfranco
Morari, Beatrice
Inglese, Alessandra
Gandolfi, Marialuisa
Smania, Nicola
Zoccante, Leonardo
author_facet Colizzi, Marco
Ciceri, Marco Luigi
Di Gennaro, Gianfranco
Morari, Beatrice
Inglese, Alessandra
Gandolfi, Marialuisa
Smania, Nicola
Zoccante, Leonardo
author_sort Colizzi, Marco
collection PubMed
description Motor abnormalities have been suggested to play a role in most neuropsychiatric disorders, as a potential generic neurodevelopmental vulnerability. However, they still represent a neglected area, with a paucity of empirical studies, especially in pediatric populations. This case-control study aimed to comprehensively assess motor functioning in children with atypical neurodevelopment and investigate whether any socio-demographic or clinical characteristics would concur with motor difficulties to distinguish children with neurodevelopmental disorders (NDD) from healthy controls. Socio-demographic (age and gender) and clinical (intelligence quotient, gait, movement, and coordination) data were collected on 114 children aged 5–15 (83 with NDD, 31 healthy controls). Male children were at significantly higher risk for NDD (OR: 13.023, p < 0.001). Furthermore, there was a statistically significant interaction between the total intelligence quotient and overall coordination such that increasing levels of total intelligence quotient appeared to protect against the likelihood of being diagnosed with an NDD, but only in the context of a preserved coordination (OR: 0.964, p = 0.038). Collectively, results may have important public health implications, as they point towards the development of new approaches to establish an early prognosis in neurodevelopment, including assessing motor difficulties and mitigating their impact on children’s quality of life.
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spelling pubmed-75656032020-10-26 Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment? Colizzi, Marco Ciceri, Marco Luigi Di Gennaro, Gianfranco Morari, Beatrice Inglese, Alessandra Gandolfi, Marialuisa Smania, Nicola Zoccante, Leonardo Brain Sci Article Motor abnormalities have been suggested to play a role in most neuropsychiatric disorders, as a potential generic neurodevelopmental vulnerability. However, they still represent a neglected area, with a paucity of empirical studies, especially in pediatric populations. This case-control study aimed to comprehensively assess motor functioning in children with atypical neurodevelopment and investigate whether any socio-demographic or clinical characteristics would concur with motor difficulties to distinguish children with neurodevelopmental disorders (NDD) from healthy controls. Socio-demographic (age and gender) and clinical (intelligence quotient, gait, movement, and coordination) data were collected on 114 children aged 5–15 (83 with NDD, 31 healthy controls). Male children were at significantly higher risk for NDD (OR: 13.023, p < 0.001). Furthermore, there was a statistically significant interaction between the total intelligence quotient and overall coordination such that increasing levels of total intelligence quotient appeared to protect against the likelihood of being diagnosed with an NDD, but only in the context of a preserved coordination (OR: 0.964, p = 0.038). Collectively, results may have important public health implications, as they point towards the development of new approaches to establish an early prognosis in neurodevelopment, including assessing motor difficulties and mitigating their impact on children’s quality of life. MDPI 2020-09-02 /pmc/articles/PMC7565603/ /pubmed/32887253 http://dx.doi.org/10.3390/brainsci10090601 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Colizzi, Marco
Ciceri, Marco Luigi
Di Gennaro, Gianfranco
Morari, Beatrice
Inglese, Alessandra
Gandolfi, Marialuisa
Smania, Nicola
Zoccante, Leonardo
Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?
title Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?
title_full Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?
title_fullStr Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?
title_full_unstemmed Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?
title_short Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?
title_sort investigating gait, movement, and coordination in children with neurodevelopmental disorders: is there a role for motor abnormalities in atypical neurodevelopment?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565603/
https://www.ncbi.nlm.nih.gov/pubmed/32887253
http://dx.doi.org/10.3390/brainsci10090601
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