Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status

Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to ca...

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Autores principales: Osu, Naoto, Kobayashi, Daijiro, Shirai, Katsuyuki, Musha, Atsushi, Sato, Hiro, Hirota, Yuka, Shibata, Atsushi, Oike, Takahiro, Ohno, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565683/
https://www.ncbi.nlm.nih.gov/pubmed/32722522
http://dx.doi.org/10.3390/jpm10030071
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author Osu, Naoto
Kobayashi, Daijiro
Shirai, Katsuyuki
Musha, Atsushi
Sato, Hiro
Hirota, Yuka
Shibata, Atsushi
Oike, Takahiro
Ohno, Tatsuya
author_facet Osu, Naoto
Kobayashi, Daijiro
Shirai, Katsuyuki
Musha, Atsushi
Sato, Hiro
Hirota, Yuka
Shibata, Atsushi
Oike, Takahiro
Ohno, Tatsuya
author_sort Osu, Naoto
collection PubMed
description Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPV-positive HNSCCs.
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spelling pubmed-75656832020-10-26 Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status Osu, Naoto Kobayashi, Daijiro Shirai, Katsuyuki Musha, Atsushi Sato, Hiro Hirota, Yuka Shibata, Atsushi Oike, Takahiro Ohno, Tatsuya J Pers Med Communication Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPV-positive HNSCCs. MDPI 2020-07-25 /pmc/articles/PMC7565683/ /pubmed/32722522 http://dx.doi.org/10.3390/jpm10030071 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Osu, Naoto
Kobayashi, Daijiro
Shirai, Katsuyuki
Musha, Atsushi
Sato, Hiro
Hirota, Yuka
Shibata, Atsushi
Oike, Takahiro
Ohno, Tatsuya
Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status
title Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status
title_full Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status
title_fullStr Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status
title_full_unstemmed Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status
title_short Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status
title_sort relative biological effectiveness of carbon ions for head-and-neck squamous cell carcinomas according to human papillomavirus status
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565683/
https://www.ncbi.nlm.nih.gov/pubmed/32722522
http://dx.doi.org/10.3390/jpm10030071
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