Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines

Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV). They have expanded in geographic distribution and refocused international attention in recent years. Vaccination is one of the most e...

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Detalles Bibliográficos
Autores principales: Zhang, Naru, Li, Chaoqun, Jiang, Shibo, Du, Lanying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565697/
https://www.ncbi.nlm.nih.gov/pubmed/32867194
http://dx.doi.org/10.3390/vaccines8030481
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author Zhang, Naru
Li, Chaoqun
Jiang, Shibo
Du, Lanying
author_facet Zhang, Naru
Li, Chaoqun
Jiang, Shibo
Du, Lanying
author_sort Zhang, Naru
collection PubMed
description Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV). They have expanded in geographic distribution and refocused international attention in recent years. Vaccination is one of the most effective public health strategies for combating flavivirus infections. In this review, we summarized virus-like particle (VLP)-based vaccines against the above four mentioned flaviviruses. Potential strategies to improve the efficacy of VLP-based flavivirus vaccines were also illustrated. The applications of flavivirus VLPs as tools for viral detection and antiviral drug screening were finally proposed.
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spelling pubmed-75656972020-10-26 Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines Zhang, Naru Li, Chaoqun Jiang, Shibo Du, Lanying Vaccines (Basel) Review Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV). They have expanded in geographic distribution and refocused international attention in recent years. Vaccination is one of the most effective public health strategies for combating flavivirus infections. In this review, we summarized virus-like particle (VLP)-based vaccines against the above four mentioned flaviviruses. Potential strategies to improve the efficacy of VLP-based flavivirus vaccines were also illustrated. The applications of flavivirus VLPs as tools for viral detection and antiviral drug screening were finally proposed. MDPI 2020-08-27 /pmc/articles/PMC7565697/ /pubmed/32867194 http://dx.doi.org/10.3390/vaccines8030481 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Naru
Li, Chaoqun
Jiang, Shibo
Du, Lanying
Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines
title Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines
title_full Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines
title_fullStr Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines
title_full_unstemmed Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines
title_short Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines
title_sort recent advances in the development of virus-like particle-based flavivirus vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565697/
https://www.ncbi.nlm.nih.gov/pubmed/32867194
http://dx.doi.org/10.3390/vaccines8030481
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