Cargando…

Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes

The administration of opioids is a central element in contemporary anesthetic techniques in Australia; however, opioids have a range of side effects. As an alternative, opioid-free anesthesia (OFA) is an emerging mode of anesthesia intended to avoid these side effects. This study is the first to pub...

Descripción completa

Detalles Bibliográficos
Autores principales: Eidan, Anthony, Ratsch, Angela, Burmeister, Elizabeth A., Griffiths, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565777/
https://www.ncbi.nlm.nih.gov/pubmed/32823720
http://dx.doi.org/10.3390/mps3030058
_version_ 1783596007060144128
author Eidan, Anthony
Ratsch, Angela
Burmeister, Elizabeth A.
Griffiths, Geraldine
author_facet Eidan, Anthony
Ratsch, Angela
Burmeister, Elizabeth A.
Griffiths, Geraldine
author_sort Eidan, Anthony
collection PubMed
description The administration of opioids is a central element in contemporary anesthetic techniques in Australia; however, opioids have a range of side effects. As an alternative, opioid-free anesthesia (OFA) is an emerging mode of anesthesia intended to avoid these side effects. This study is the first to publish the use of OFA in Australia and is conducted in a regional Queensland Health Service. The design will utilize a randomized clinical trial (RCT) to investigate the impact of OFA for patients having an elective laparoscopic cholecystectomy (n = 40) or tubal ligation (n = 40). Participant outcomes to be measured include: Quality of Recovery (QoR-15); Oral Morphine Equivalent Daily Dose (OMEDD) at 24-h post-operatively; time to first opioid (TTFO) dose; post-operative nausea and vomiting (PONV); Post Anesthetic Care Unit length of stay (PACU-LOS); and hospital length of stay (LOS). The findings may challenge the essentiality of opioids in the peri-operative period, which in turn would influence the future intra-operative management of surgical patients. Ultimately, a reduction in anesthesia-associated opioid use will support a more general decline in opioid use.
format Online
Article
Text
id pubmed-7565777
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75657772020-10-26 Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes Eidan, Anthony Ratsch, Angela Burmeister, Elizabeth A. Griffiths, Geraldine Methods Protoc Protocol The administration of opioids is a central element in contemporary anesthetic techniques in Australia; however, opioids have a range of side effects. As an alternative, opioid-free anesthesia (OFA) is an emerging mode of anesthesia intended to avoid these side effects. This study is the first to publish the use of OFA in Australia and is conducted in a regional Queensland Health Service. The design will utilize a randomized clinical trial (RCT) to investigate the impact of OFA for patients having an elective laparoscopic cholecystectomy (n = 40) or tubal ligation (n = 40). Participant outcomes to be measured include: Quality of Recovery (QoR-15); Oral Morphine Equivalent Daily Dose (OMEDD) at 24-h post-operatively; time to first opioid (TTFO) dose; post-operative nausea and vomiting (PONV); Post Anesthetic Care Unit length of stay (PACU-LOS); and hospital length of stay (LOS). The findings may challenge the essentiality of opioids in the peri-operative period, which in turn would influence the future intra-operative management of surgical patients. Ultimately, a reduction in anesthesia-associated opioid use will support a more general decline in opioid use. MDPI 2020-08-13 /pmc/articles/PMC7565777/ /pubmed/32823720 http://dx.doi.org/10.3390/mps3030058 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Eidan, Anthony
Ratsch, Angela
Burmeister, Elizabeth A.
Griffiths, Geraldine
Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes
title Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes
title_full Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes
title_fullStr Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes
title_full_unstemmed Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes
title_short Comparison of Opioid-Free Anesthesia Versus Opioid-Containing Anesthesia for Elective Laparoscopic Surgery (COFA: LAP): A Protocol Measuring Recovery Outcomes
title_sort comparison of opioid-free anesthesia versus opioid-containing anesthesia for elective laparoscopic surgery (cofa: lap): a protocol measuring recovery outcomes
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565777/
https://www.ncbi.nlm.nih.gov/pubmed/32823720
http://dx.doi.org/10.3390/mps3030058
work_keys_str_mv AT eidananthony comparisonofopioidfreeanesthesiaversusopioidcontaininganesthesiaforelectivelaparoscopicsurgerycofalapaprotocolmeasuringrecoveryoutcomes
AT ratschangela comparisonofopioidfreeanesthesiaversusopioidcontaininganesthesiaforelectivelaparoscopicsurgerycofalapaprotocolmeasuringrecoveryoutcomes
AT burmeisterelizabetha comparisonofopioidfreeanesthesiaversusopioidcontaininganesthesiaforelectivelaparoscopicsurgerycofalapaprotocolmeasuringrecoveryoutcomes
AT griffithsgeraldine comparisonofopioidfreeanesthesiaversusopioidcontaininganesthesiaforelectivelaparoscopicsurgerycofalapaprotocolmeasuringrecoveryoutcomes