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Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine
BACKGROUND: Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565835/ https://www.ncbi.nlm.nih.gov/pubmed/33066795 http://dx.doi.org/10.1186/s12989-020-00372-0 |
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author | Feng, Xiaoli Zhang, Yaqing Zhang, Chao Lai, Xuan Zhang, Yanli Wu, Junrong Hu, Chen Shao, Longquan |
author_facet | Feng, Xiaoli Zhang, Yaqing Zhang, Chao Lai, Xuan Zhang, Yanli Wu, Junrong Hu, Chen Shao, Longquan |
author_sort | Feng, Xiaoli |
collection | PubMed |
description | BACKGROUND: Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. MAIN BODY: We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. CONCLUSION: In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible. |
format | Online Article Text |
id | pubmed-7565835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75658352020-10-20 Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine Feng, Xiaoli Zhang, Yaqing Zhang, Chao Lai, Xuan Zhang, Yanli Wu, Junrong Hu, Chen Shao, Longquan Part Fibre Toxicol Review BACKGROUND: Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. MAIN BODY: We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. CONCLUSION: In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible. BioMed Central 2020-10-16 /pmc/articles/PMC7565835/ /pubmed/33066795 http://dx.doi.org/10.1186/s12989-020-00372-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Feng, Xiaoli Zhang, Yaqing Zhang, Chao Lai, Xuan Zhang, Yanli Wu, Junrong Hu, Chen Shao, Longquan Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine |
title | Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine |
title_full | Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine |
title_fullStr | Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine |
title_full_unstemmed | Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine |
title_short | Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine |
title_sort | nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565835/ https://www.ncbi.nlm.nih.gov/pubmed/33066795 http://dx.doi.org/10.1186/s12989-020-00372-0 |
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