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Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa

Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl...

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Autores principales: Duriez, Philibert, Robichon, Lauralee, Dardennes, Roland, Lavoisy, Guillaume, Grouselle, Dominique, Epelbaum, Jacques, Ramoz, Nicolas, Gorwood, Philip, Tolle, Virginie, Viltart, Odile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565884/
https://www.ncbi.nlm.nih.gov/pubmed/32872151
http://dx.doi.org/10.3390/jcm9092782
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author Duriez, Philibert
Robichon, Lauralee
Dardennes, Roland
Lavoisy, Guillaume
Grouselle, Dominique
Epelbaum, Jacques
Ramoz, Nicolas
Gorwood, Philip
Tolle, Virginie
Viltart, Odile
author_facet Duriez, Philibert
Robichon, Lauralee
Dardennes, Roland
Lavoisy, Guillaume
Grouselle, Dominique
Epelbaum, Jacques
Ramoz, Nicolas
Gorwood, Philip
Tolle, Virginie
Viltart, Odile
author_sort Duriez, Philibert
collection PubMed
description Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl—(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, n = 29), half—(T1) and total (T2) weight recovery, and one month after discharge (T3, n = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short—(15 days) or long—(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN.
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spelling pubmed-75658842020-10-26 Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa Duriez, Philibert Robichon, Lauralee Dardennes, Roland Lavoisy, Guillaume Grouselle, Dominique Epelbaum, Jacques Ramoz, Nicolas Gorwood, Philip Tolle, Virginie Viltart, Odile J Clin Med Article Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl—(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, n = 29), half—(T1) and total (T2) weight recovery, and one month after discharge (T3, n = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short—(15 days) or long—(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN. MDPI 2020-08-28 /pmc/articles/PMC7565884/ /pubmed/32872151 http://dx.doi.org/10.3390/jcm9092782 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duriez, Philibert
Robichon, Lauralee
Dardennes, Roland
Lavoisy, Guillaume
Grouselle, Dominique
Epelbaum, Jacques
Ramoz, Nicolas
Gorwood, Philip
Tolle, Virginie
Viltart, Odile
Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa
title Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa
title_full Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa
title_fullStr Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa
title_full_unstemmed Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa
title_short Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa
title_sort unexpected association of desacyl-ghrelin with physical activity and chronic food restriction: a translational study on anorexia nervosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565884/
https://www.ncbi.nlm.nih.gov/pubmed/32872151
http://dx.doi.org/10.3390/jcm9092782
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