Cargando…
On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in t...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565917/ https://www.ncbi.nlm.nih.gov/pubmed/32932841 http://dx.doi.org/10.3390/cells9092079 |
_version_ | 1783596038464995328 |
---|---|
author | Santocki, Michal Kolaczkowska, Elzbieta |
author_facet | Santocki, Michal Kolaczkowska, Elzbieta |
author_sort | Santocki, Michal |
collection | PubMed |
description | Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they are removed in mild pathophysiological conditions and why their removal is impaired in multiple severe pathological conditions. Herein, we bring together all data available up till now on how NETs are cleared—from engaged cells, their phenotypes, to involved enzymes and molecules. Moreover, we hypothesize on why NET removal is challenged in multiple disorders and propose further directions for studies on NET removal as well as possible therapeutic strategies to have them cleared. |
format | Online Article Text |
id | pubmed-7565917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75659172020-10-26 On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little Santocki, Michal Kolaczkowska, Elzbieta Cells Review Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they are removed in mild pathophysiological conditions and why their removal is impaired in multiple severe pathological conditions. Herein, we bring together all data available up till now on how NETs are cleared—from engaged cells, their phenotypes, to involved enzymes and molecules. Moreover, we hypothesize on why NET removal is challenged in multiple disorders and propose further directions for studies on NET removal as well as possible therapeutic strategies to have them cleared. MDPI 2020-09-11 /pmc/articles/PMC7565917/ /pubmed/32932841 http://dx.doi.org/10.3390/cells9092079 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Santocki, Michal Kolaczkowska, Elzbieta On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little |
title | On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little |
title_full | On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little |
title_fullStr | On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little |
title_full_unstemmed | On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little |
title_short | On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little |
title_sort | on neutrophil extracellular trap (net) removal: what we know thus far and why so little |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565917/ https://www.ncbi.nlm.nih.gov/pubmed/32932841 http://dx.doi.org/10.3390/cells9092079 |
work_keys_str_mv | AT santockimichal onneutrophilextracellulartrapnetremovalwhatweknowthusfarandwhysolittle AT kolaczkowskaelzbieta onneutrophilextracellulartrapnetremovalwhatweknowthusfarandwhysolittle |