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On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little

Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in t...

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Detalles Bibliográficos
Autores principales: Santocki, Michal, Kolaczkowska, Elzbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565917/
https://www.ncbi.nlm.nih.gov/pubmed/32932841
http://dx.doi.org/10.3390/cells9092079
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author Santocki, Michal
Kolaczkowska, Elzbieta
author_facet Santocki, Michal
Kolaczkowska, Elzbieta
author_sort Santocki, Michal
collection PubMed
description Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they are removed in mild pathophysiological conditions and why their removal is impaired in multiple severe pathological conditions. Herein, we bring together all data available up till now on how NETs are cleared—from engaged cells, their phenotypes, to involved enzymes and molecules. Moreover, we hypothesize on why NET removal is challenged in multiple disorders and propose further directions for studies on NET removal as well as possible therapeutic strategies to have them cleared.
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spelling pubmed-75659172020-10-26 On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little Santocki, Michal Kolaczkowska, Elzbieta Cells Review Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they are removed in mild pathophysiological conditions and why their removal is impaired in multiple severe pathological conditions. Herein, we bring together all data available up till now on how NETs are cleared—from engaged cells, their phenotypes, to involved enzymes and molecules. Moreover, we hypothesize on why NET removal is challenged in multiple disorders and propose further directions for studies on NET removal as well as possible therapeutic strategies to have them cleared. MDPI 2020-09-11 /pmc/articles/PMC7565917/ /pubmed/32932841 http://dx.doi.org/10.3390/cells9092079 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Santocki, Michal
Kolaczkowska, Elzbieta
On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
title On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
title_full On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
title_fullStr On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
title_full_unstemmed On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
title_short On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
title_sort on neutrophil extracellular trap (net) removal: what we know thus far and why so little
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565917/
https://www.ncbi.nlm.nih.gov/pubmed/32932841
http://dx.doi.org/10.3390/cells9092079
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