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The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey
The present study aims to evaluate whether influenza and pneumococcal vaccinations are associated with positive nasopharyngeal swab (NPS) testing to detect SARS-CoV-2. Data from the Italian cross-sectional web-based survey (EPICOVID19), based on a self-selection sample of individuals aged ≥18, were...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565943/ https://www.ncbi.nlm.nih.gov/pubmed/32842505 http://dx.doi.org/10.3390/vaccines8030471 |
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author | Noale, Marianna Trevisan, Caterina Maggi, Stefania Antonelli Incalzi, Raffaele Pedone, Claudio Di Bari, Mauro Adorni, Fulvio Jesuthasan, Nithiya Sojic, Aleksandra Galli, Massimo Giacomelli, Andrea Molinaro, Sabrina Bianchi, Fabrizio Mastroianni, Claudio Prinelli, Federica Group, on behalf of the EPICOVID19 Working |
author_facet | Noale, Marianna Trevisan, Caterina Maggi, Stefania Antonelli Incalzi, Raffaele Pedone, Claudio Di Bari, Mauro Adorni, Fulvio Jesuthasan, Nithiya Sojic, Aleksandra Galli, Massimo Giacomelli, Andrea Molinaro, Sabrina Bianchi, Fabrizio Mastroianni, Claudio Prinelli, Federica Group, on behalf of the EPICOVID19 Working |
author_sort | Noale, Marianna |
collection | PubMed |
description | The present study aims to evaluate whether influenza and pneumococcal vaccinations are associated with positive nasopharyngeal swab (NPS) testing to detect SARS-CoV-2. Data from the Italian cross-sectional web-based survey (EPICOVID19), based on a self-selection sample of individuals aged ≥18, were considered. The probability of a positive SARS-CoV-2 NPS test result as a function of influenza or anti-pneumococcal vaccination was evaluated using multivariable logistic regression, stratifying analysis by age (<65 years, ≥65 years). From April 2020, 170,731 individuals aged <65 years and 28,097 ≥65 years filled out the EPICOVID19 questionnaire. Influenza and anti-pneumococcal vaccinations were received, respectively, by 16% and 2% of those <65 years, and by 53% and 13% of those ≥65 years. SARS-CoV-2 NPS testing was reported by 6680 participants. Anti-pneumococcal and influenza vaccinations were associated with a decreased probability of a SARS-CoV-2 NPS positive test in the younger participants (OR = 0.61, 95% CI 0.41–0.91; OR = 0.85, 95%CI 0.74–0.98; respectively). A significantly lower probability of a positive test result was detected in the individuals ≥65 years who received anti-pneumococcal vaccination (OR = 0.56, 95%CI 0.33–0.95). These results need to be confirmed by further investigations, but they are relevant given the probable coexistence of influenza, bacterial infections, and COVID-19 over the coming autumn–winter season. |
format | Online Article Text |
id | pubmed-7565943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75659432020-10-26 The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey Noale, Marianna Trevisan, Caterina Maggi, Stefania Antonelli Incalzi, Raffaele Pedone, Claudio Di Bari, Mauro Adorni, Fulvio Jesuthasan, Nithiya Sojic, Aleksandra Galli, Massimo Giacomelli, Andrea Molinaro, Sabrina Bianchi, Fabrizio Mastroianni, Claudio Prinelli, Federica Group, on behalf of the EPICOVID19 Working Vaccines (Basel) Article The present study aims to evaluate whether influenza and pneumococcal vaccinations are associated with positive nasopharyngeal swab (NPS) testing to detect SARS-CoV-2. Data from the Italian cross-sectional web-based survey (EPICOVID19), based on a self-selection sample of individuals aged ≥18, were considered. The probability of a positive SARS-CoV-2 NPS test result as a function of influenza or anti-pneumococcal vaccination was evaluated using multivariable logistic regression, stratifying analysis by age (<65 years, ≥65 years). From April 2020, 170,731 individuals aged <65 years and 28,097 ≥65 years filled out the EPICOVID19 questionnaire. Influenza and anti-pneumococcal vaccinations were received, respectively, by 16% and 2% of those <65 years, and by 53% and 13% of those ≥65 years. SARS-CoV-2 NPS testing was reported by 6680 participants. Anti-pneumococcal and influenza vaccinations were associated with a decreased probability of a SARS-CoV-2 NPS positive test in the younger participants (OR = 0.61, 95% CI 0.41–0.91; OR = 0.85, 95%CI 0.74–0.98; respectively). A significantly lower probability of a positive test result was detected in the individuals ≥65 years who received anti-pneumococcal vaccination (OR = 0.56, 95%CI 0.33–0.95). These results need to be confirmed by further investigations, but they are relevant given the probable coexistence of influenza, bacterial infections, and COVID-19 over the coming autumn–winter season. MDPI 2020-08-23 /pmc/articles/PMC7565943/ /pubmed/32842505 http://dx.doi.org/10.3390/vaccines8030471 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Noale, Marianna Trevisan, Caterina Maggi, Stefania Antonelli Incalzi, Raffaele Pedone, Claudio Di Bari, Mauro Adorni, Fulvio Jesuthasan, Nithiya Sojic, Aleksandra Galli, Massimo Giacomelli, Andrea Molinaro, Sabrina Bianchi, Fabrizio Mastroianni, Claudio Prinelli, Federica Group, on behalf of the EPICOVID19 Working The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey |
title | The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey |
title_full | The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey |
title_fullStr | The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey |
title_full_unstemmed | The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey |
title_short | The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey |
title_sort | association between influenza and pneumococcal vaccinations and sars-cov-2 infection: data from the epicovid19 web-based survey |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565943/ https://www.ncbi.nlm.nih.gov/pubmed/32842505 http://dx.doi.org/10.3390/vaccines8030471 |
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