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The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey

The present study aims to evaluate whether influenza and pneumococcal vaccinations are associated with positive nasopharyngeal swab (NPS) testing to detect SARS-CoV-2. Data from the Italian cross-sectional web-based survey (EPICOVID19), based on a self-selection sample of individuals aged ≥18, were...

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Autores principales: Noale, Marianna, Trevisan, Caterina, Maggi, Stefania, Antonelli Incalzi, Raffaele, Pedone, Claudio, Di Bari, Mauro, Adorni, Fulvio, Jesuthasan, Nithiya, Sojic, Aleksandra, Galli, Massimo, Giacomelli, Andrea, Molinaro, Sabrina, Bianchi, Fabrizio, Mastroianni, Claudio, Prinelli, Federica, Group, on behalf of the EPICOVID19 Working
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565943/
https://www.ncbi.nlm.nih.gov/pubmed/32842505
http://dx.doi.org/10.3390/vaccines8030471
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author Noale, Marianna
Trevisan, Caterina
Maggi, Stefania
Antonelli Incalzi, Raffaele
Pedone, Claudio
Di Bari, Mauro
Adorni, Fulvio
Jesuthasan, Nithiya
Sojic, Aleksandra
Galli, Massimo
Giacomelli, Andrea
Molinaro, Sabrina
Bianchi, Fabrizio
Mastroianni, Claudio
Prinelli, Federica
Group, on behalf of the EPICOVID19 Working
author_facet Noale, Marianna
Trevisan, Caterina
Maggi, Stefania
Antonelli Incalzi, Raffaele
Pedone, Claudio
Di Bari, Mauro
Adorni, Fulvio
Jesuthasan, Nithiya
Sojic, Aleksandra
Galli, Massimo
Giacomelli, Andrea
Molinaro, Sabrina
Bianchi, Fabrizio
Mastroianni, Claudio
Prinelli, Federica
Group, on behalf of the EPICOVID19 Working
author_sort Noale, Marianna
collection PubMed
description The present study aims to evaluate whether influenza and pneumococcal vaccinations are associated with positive nasopharyngeal swab (NPS) testing to detect SARS-CoV-2. Data from the Italian cross-sectional web-based survey (EPICOVID19), based on a self-selection sample of individuals aged ≥18, were considered. The probability of a positive SARS-CoV-2 NPS test result as a function of influenza or anti-pneumococcal vaccination was evaluated using multivariable logistic regression, stratifying analysis by age (<65 years, ≥65 years). From April 2020, 170,731 individuals aged <65 years and 28,097 ≥65 years filled out the EPICOVID19 questionnaire. Influenza and anti-pneumococcal vaccinations were received, respectively, by 16% and 2% of those <65 years, and by 53% and 13% of those ≥65 years. SARS-CoV-2 NPS testing was reported by 6680 participants. Anti-pneumococcal and influenza vaccinations were associated with a decreased probability of a SARS-CoV-2 NPS positive test in the younger participants (OR = 0.61, 95% CI 0.41–0.91; OR = 0.85, 95%CI 0.74–0.98; respectively). A significantly lower probability of a positive test result was detected in the individuals ≥65 years who received anti-pneumococcal vaccination (OR = 0.56, 95%CI 0.33–0.95). These results need to be confirmed by further investigations, but they are relevant given the probable coexistence of influenza, bacterial infections, and COVID-19 over the coming autumn–winter season.
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spelling pubmed-75659432020-10-26 The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey Noale, Marianna Trevisan, Caterina Maggi, Stefania Antonelli Incalzi, Raffaele Pedone, Claudio Di Bari, Mauro Adorni, Fulvio Jesuthasan, Nithiya Sojic, Aleksandra Galli, Massimo Giacomelli, Andrea Molinaro, Sabrina Bianchi, Fabrizio Mastroianni, Claudio Prinelli, Federica Group, on behalf of the EPICOVID19 Working Vaccines (Basel) Article The present study aims to evaluate whether influenza and pneumococcal vaccinations are associated with positive nasopharyngeal swab (NPS) testing to detect SARS-CoV-2. Data from the Italian cross-sectional web-based survey (EPICOVID19), based on a self-selection sample of individuals aged ≥18, were considered. The probability of a positive SARS-CoV-2 NPS test result as a function of influenza or anti-pneumococcal vaccination was evaluated using multivariable logistic regression, stratifying analysis by age (<65 years, ≥65 years). From April 2020, 170,731 individuals aged <65 years and 28,097 ≥65 years filled out the EPICOVID19 questionnaire. Influenza and anti-pneumococcal vaccinations were received, respectively, by 16% and 2% of those <65 years, and by 53% and 13% of those ≥65 years. SARS-CoV-2 NPS testing was reported by 6680 participants. Anti-pneumococcal and influenza vaccinations were associated with a decreased probability of a SARS-CoV-2 NPS positive test in the younger participants (OR = 0.61, 95% CI 0.41–0.91; OR = 0.85, 95%CI 0.74–0.98; respectively). A significantly lower probability of a positive test result was detected in the individuals ≥65 years who received anti-pneumococcal vaccination (OR = 0.56, 95%CI 0.33–0.95). These results need to be confirmed by further investigations, but they are relevant given the probable coexistence of influenza, bacterial infections, and COVID-19 over the coming autumn–winter season. MDPI 2020-08-23 /pmc/articles/PMC7565943/ /pubmed/32842505 http://dx.doi.org/10.3390/vaccines8030471 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Noale, Marianna
Trevisan, Caterina
Maggi, Stefania
Antonelli Incalzi, Raffaele
Pedone, Claudio
Di Bari, Mauro
Adorni, Fulvio
Jesuthasan, Nithiya
Sojic, Aleksandra
Galli, Massimo
Giacomelli, Andrea
Molinaro, Sabrina
Bianchi, Fabrizio
Mastroianni, Claudio
Prinelli, Federica
Group, on behalf of the EPICOVID19 Working
The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey
title The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey
title_full The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey
title_fullStr The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey
title_full_unstemmed The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey
title_short The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey
title_sort association between influenza and pneumococcal vaccinations and sars-cov-2 infection: data from the epicovid19 web-based survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565943/
https://www.ncbi.nlm.nih.gov/pubmed/32842505
http://dx.doi.org/10.3390/vaccines8030471
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