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Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report

Hepatitis E virus (HEV) is an emergent zoonotic pathogen, causing worldwide acute and chronic hepatitis in humans. HEV comprises eight genotypes and several subtypes. HEV genotypes 3 and 4 (HEV3 and HEV4) are zoonotic. In Italy, the most part of HEV infections (80%) is due to autochthonous HEV3 circ...

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Autores principales: Aprea, Giuseppe, Scattolini, Silvia, D’Angelantonio, Daniela, Chiaverini, Alexandra, Di Lollo, Valeria, Olivieri, Sabrina, Marcacci, Maurilia, Mangone, Iolanda, Salucci, Stefania, Antoci, Salvatore, Cammà, Cesare, Di Pasquale, Adriano, Migliorati, Giacomo, Pomilio, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565956/
https://www.ncbi.nlm.nih.gov/pubmed/32932776
http://dx.doi.org/10.3390/microorganisms8091393
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author Aprea, Giuseppe
Scattolini, Silvia
D’Angelantonio, Daniela
Chiaverini, Alexandra
Di Lollo, Valeria
Olivieri, Sabrina
Marcacci, Maurilia
Mangone, Iolanda
Salucci, Stefania
Antoci, Salvatore
Cammà, Cesare
Di Pasquale, Adriano
Migliorati, Giacomo
Pomilio, Francesco
author_facet Aprea, Giuseppe
Scattolini, Silvia
D’Angelantonio, Daniela
Chiaverini, Alexandra
Di Lollo, Valeria
Olivieri, Sabrina
Marcacci, Maurilia
Mangone, Iolanda
Salucci, Stefania
Antoci, Salvatore
Cammà, Cesare
Di Pasquale, Adriano
Migliorati, Giacomo
Pomilio, Francesco
author_sort Aprea, Giuseppe
collection PubMed
description Hepatitis E virus (HEV) is an emergent zoonotic pathogen, causing worldwide acute and chronic hepatitis in humans. HEV comprises eight genotypes and several subtypes. HEV genotypes 3 and 4 (HEV3 and HEV4) are zoonotic. In Italy, the most part of HEV infections (80%) is due to autochthonous HEV3 circulation of the virus, and the key role played by wild animals is generally accepted. Abruzzo is an Italian region officially considered an HEV “hot spot”, with subtype HEV3-c being up to now the only one reported among wild boars. During the year 2018–2019, a group of wild boars in Abruzzo were screened for HEV; positive RNA liver samples were subjected to HEV characterization by using the whole genome sequencing (WGS) approach methodology. This represents the first report about the detection of HEV-3 subtypes e and f in the wild boar population in this area. Since in Italy human infections from HEV 3-e and f have been associated with pork meat consumption, our findings deserve more in-depth analysis with the aim of evaluating any potential correlation between wild animals, the pork chain production and HEV human infections.
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spelling pubmed-75659562020-10-26 Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report Aprea, Giuseppe Scattolini, Silvia D’Angelantonio, Daniela Chiaverini, Alexandra Di Lollo, Valeria Olivieri, Sabrina Marcacci, Maurilia Mangone, Iolanda Salucci, Stefania Antoci, Salvatore Cammà, Cesare Di Pasquale, Adriano Migliorati, Giacomo Pomilio, Francesco Microorganisms Article Hepatitis E virus (HEV) is an emergent zoonotic pathogen, causing worldwide acute and chronic hepatitis in humans. HEV comprises eight genotypes and several subtypes. HEV genotypes 3 and 4 (HEV3 and HEV4) are zoonotic. In Italy, the most part of HEV infections (80%) is due to autochthonous HEV3 circulation of the virus, and the key role played by wild animals is generally accepted. Abruzzo is an Italian region officially considered an HEV “hot spot”, with subtype HEV3-c being up to now the only one reported among wild boars. During the year 2018–2019, a group of wild boars in Abruzzo were screened for HEV; positive RNA liver samples were subjected to HEV characterization by using the whole genome sequencing (WGS) approach methodology. This represents the first report about the detection of HEV-3 subtypes e and f in the wild boar population in this area. Since in Italy human infections from HEV 3-e and f have been associated with pork meat consumption, our findings deserve more in-depth analysis with the aim of evaluating any potential correlation between wild animals, the pork chain production and HEV human infections. MDPI 2020-09-11 /pmc/articles/PMC7565956/ /pubmed/32932776 http://dx.doi.org/10.3390/microorganisms8091393 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aprea, Giuseppe
Scattolini, Silvia
D’Angelantonio, Daniela
Chiaverini, Alexandra
Di Lollo, Valeria
Olivieri, Sabrina
Marcacci, Maurilia
Mangone, Iolanda
Salucci, Stefania
Antoci, Salvatore
Cammà, Cesare
Di Pasquale, Adriano
Migliorati, Giacomo
Pomilio, Francesco
Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report
title Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report
title_full Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report
title_fullStr Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report
title_full_unstemmed Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report
title_short Whole Genome Sequencing Characterization of HEV3-e and HEV3-f Subtypes among the Wild Boar Population in the Abruzzo Region, Italy: First Report
title_sort whole genome sequencing characterization of hev3-e and hev3-f subtypes among the wild boar population in the abruzzo region, italy: first report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565956/
https://www.ncbi.nlm.nih.gov/pubmed/32932776
http://dx.doi.org/10.3390/microorganisms8091393
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