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Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline

BACKGROUND: Whole‐cell phenotypic screening is the driving force behind modern anti‐tubercular drug discovery efforts. Focus has shifted from screening for bactericidal scaffolds to screens incorporating target deconvolution. Target‐based screening aims to direct drug discovery toward known effectiv...

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Detalles Bibliográficos
Autores principales:	Burke, Christopher, Jankute, Monika, Moynihan, Patrick, Gonzalez del Rio, Ruben, Li, Xiaojun, Esquivias, Jorge, Lelièvre, Joël, Cox, Jonathan A. G., Sacchettini, James, Besra, Gurdyal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566049/ https://www.ncbi.nlm.nih.gov/pubmed/33089076 http://dx.doi.org/10.1096/fba.2020-00022

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