Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes

In the current adoptive T cell therapy, T cells from a patient are given back to that patient after ex vivo activation, expansion, or genetic manipulation. However, such strategy depends on the quality of the patient’s T cells, sometimes leading to treatment failure. It would therefore be ideal to u...

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Detalles Bibliográficos
Autores principales: Maeda, Takuya, Nagano, Seiji, Kashima, Soki, Terada, Koji, Agata, Yasutoshi, Ichise, Hiroshi, Ohtaka, Manami, Nakanishi, Mahito, Fujiki, Fumihiro, Sugiyama, Haruo, Kitawaki, Toshio, Kadowaki, Norimitsu, Takaori-Kondo, Akifumi, Masuda, Kyoko, Kawamoto, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566080/
https://www.ncbi.nlm.nih.gov/pubmed/33102617
http://dx.doi.org/10.1016/j.omtm.2020.09.011

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