A Rapid Caspase-11 Response Induced by IFNγ Priming Is Independent of Guanylate Binding Proteins

In mammalian cells, inflammatory caspases detect Gram-negative bacterial invasion by binding lipopolysaccharides (LPS). Murine caspase-11 binds cytosolic LPS, stimulates pyroptotic cell death, and drives sepsis pathogenesis. Extracellular priming factors enhance caspase-11-dependent pyroptosis. Here...

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Detalles Bibliográficos
Autores principales: Brubaker, Sky W., Brewer, Susan M., Massis, Liliana M., Napier, Brooke A., Monack, Denise M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566093/
https://www.ncbi.nlm.nih.gov/pubmed/33089101
http://dx.doi.org/10.1016/j.isci.2020.101612

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