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Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion
Autologous chimeric antigen receptor engineered T-cell therapies are beginning to dramatically change the outlook for patients with several hematological malignancies. Yet methods to activate and expand these cells are limited, often pose challenges to automation, and have biological limitations imp...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Lippincott Williams & Wilkins
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566300/ https://www.ncbi.nlm.nih.gov/pubmed/32796275 http://dx.doi.org/10.1097/CJI.0000000000000329 |
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| author | Keskar, Vandana Sood, Anup Loghin, Evelina Kovacs, Ernest Duthie, R. Scott Liu, Shutong Park, Jee Hyun Chadwick, Chrystal Smith, Reginald Brown, Martin Stroncek, David F. Highfill, Steven L. |
| author_facet | Keskar, Vandana Sood, Anup Loghin, Evelina Kovacs, Ernest Duthie, R. Scott Liu, Shutong Park, Jee Hyun Chadwick, Chrystal Smith, Reginald Brown, Martin Stroncek, David F. Highfill, Steven L. |
| author_sort | Keskar, Vandana |
| collection | PubMed |
| description | Autologous chimeric antigen receptor engineered T-cell therapies are beginning to dramatically change the outlook for patients with several hematological malignancies. Yet methods to activate and expand these cells are limited, often pose challenges to automation, and have biological limitations impacting the output of the injectable dose. This study describes the development of a novel, highly flexible, soluble DNA-based T-cell activation and expansion platform which alleviates the limitations of current technologies and provides rapid T-cell activation and expansion. |
| format | Online Article Text |
| id | pubmed-7566300 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Lippincott Williams & Wilkins |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75663002020-10-29 Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion Keskar, Vandana Sood, Anup Loghin, Evelina Kovacs, Ernest Duthie, R. Scott Liu, Shutong Park, Jee Hyun Chadwick, Chrystal Smith, Reginald Brown, Martin Stroncek, David F. Highfill, Steven L. J Immunother Basic Studies Autologous chimeric antigen receptor engineered T-cell therapies are beginning to dramatically change the outlook for patients with several hematological malignancies. Yet methods to activate and expand these cells are limited, often pose challenges to automation, and have biological limitations impacting the output of the injectable dose. This study describes the development of a novel, highly flexible, soluble DNA-based T-cell activation and expansion platform which alleviates the limitations of current technologies and provides rapid T-cell activation and expansion. Lippincott Williams & Wilkins 2020-10 2020-08-18 /pmc/articles/PMC7566300/ /pubmed/32796275 http://dx.doi.org/10.1097/CJI.0000000000000329 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| spellingShingle | Basic Studies Keskar, Vandana Sood, Anup Loghin, Evelina Kovacs, Ernest Duthie, R. Scott Liu, Shutong Park, Jee Hyun Chadwick, Chrystal Smith, Reginald Brown, Martin Stroncek, David F. Highfill, Steven L. Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion |
| title | Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion |
| title_full | Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion |
| title_fullStr | Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion |
| title_full_unstemmed | Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion |
| title_short | Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion |
| title_sort | novel dna-based t-cell activator promotes rapid t-cell activation and expansion |
| topic | Basic Studies |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566300/ https://www.ncbi.nlm.nih.gov/pubmed/32796275 http://dx.doi.org/10.1097/CJI.0000000000000329 |
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