An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility

BACKGROUND: DNA methylation acts as a mechanism of gene transcription regulation. It has recently gained attention as a possible therapeutic target in cardiac hypertrophy and heart failure. However, its exact role in cardiomyocytes remains controversial. Thus, we knocked out the main de novo DNA met...

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Detalles Bibliográficos
Autores principales: Madsen, Alexandra, Höppner, Grit, Krause, Julia, Hirt, Marc N., Laufer, Sandra D., Schweizer, Michaela, Tan, Wilson Lek Wen, Mosqueira, Diogo, Anene-Nzelu, Chukwuemeka George, Lim, Ives, Foo, Roger S.Y., Hansen, Arne, Eschenhagen, Thomas, Stenzig, Justus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566310/
https://www.ncbi.nlm.nih.gov/pubmed/32885664
http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566310/
https://www.ncbi.nlm.nih.gov/pubmed/32885664
http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044444

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