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PDX: Moving Beyond Drug Screening to Versatile Models for Research Discovery

Patient-derived xenografts (PDXs) are tools of the trade for many researchers from all disciplines and medical specialties. Most endocrinologists, and especially those working in oncology, commonly use PDXs for preclinical drug testing and development, and over the last decade large collections of P...

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Detalles Bibliográficos
Autores principales: Risbridger, Gail P, Lawrence, Mitchell G, Taylor, Renea A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566391/
https://www.ncbi.nlm.nih.gov/pubmed/33094211
http://dx.doi.org/10.1210/jendso/bvaa132
Descripción
Sumario:Patient-derived xenografts (PDXs) are tools of the trade for many researchers from all disciplines and medical specialties. Most endocrinologists, and especially those working in oncology, commonly use PDXs for preclinical drug testing and development, and over the last decade large collections of PDXs have emerged across all tumor streams. In this review, we examine how the field has evolved to include PDXs as versatile resources for research discoveries, providing evidence for guidelines and changes in clinical practice.