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Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy
OBJECTIVES: We conducted a systematic review and meta-analysis of studies that compared levels of molecular biomarkers in women with peripartum cardiomyopathy (PPCM) to those in healthy pregnant and postpartum women to: (1) assess the evidence for prolactin (PRL) metabolism in PPCM, (2) ascertain th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566429/ https://www.ncbi.nlm.nih.gov/pubmed/33060142 http://dx.doi.org/10.1136/openhrt-2020-001430 |
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author | Cherubin, Sinaida Peoples, Taylar Gillard, Jessica Lakhal-Littleton, Samira Kurinczuk, Jennifer J Nair, Manisha |
author_facet | Cherubin, Sinaida Peoples, Taylar Gillard, Jessica Lakhal-Littleton, Samira Kurinczuk, Jennifer J Nair, Manisha |
author_sort | Cherubin, Sinaida |
collection | PubMed |
description | OBJECTIVES: We conducted a systematic review and meta-analysis of studies that compared levels of molecular biomarkers in women with peripartum cardiomyopathy (PPCM) to those in healthy pregnant and postpartum women to: (1) assess the evidence for prolactin (PRL) metabolism in PPCM, (2) ascertain the evidence for biomarkers of iron deficiency in PPCM, (3) identify other biomarkers associated with PPCM. METHODS: We searched Medline, Embase, Cumulated Index to Nursing and Allied Health Literature (CINAHL) and the Global Health Library from inception without language restriction for studies that compared biomarkers levels in PPCM cases to healthy controls. Pooled standardised mean difference (SMD) was generated using a random effects model for the difference in levels of biomarkers. RESULTS: Two studies assessed the association of PRL with PPCM, and reported that PPCM cases have higher levels of total PRL. No studies investigated iron metabolism in PPCM. Other biomarkers associated with PPCM included serum levels of natriuretic peptides (SMD=3.77, 95% CI 0.71 to 6.82), albumin (SMD=-0.67, 95% CI -1.01 to -0.32), C-reactive protein (SMD=1.67, 95% CI 0.22 to 3.12), selenium (SMD=-0.73, 95% CI -1.58 to 0.12), cardiac troponins (SMD=1.06, 95% CI 0.33 to 1.80), creatinine (SMD=0.51, 95% CI 0.33 to 0.69), white bloodcells (SMD=0.44, 95 % CI 0.07 to 0.82), haemoglobin (SMD=-0.45, 95% CI -0.64 to-0.26). CONCLUSIONS: More robust molecular studies are needed to explore the association between prolactin and PPCM in human subjects and to determine the extent to which iron deficiency (with or without anaemia) contributes to the risk of PPCM. |
format | Online Article Text |
id | pubmed-7566429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-75664292020-10-19 Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy Cherubin, Sinaida Peoples, Taylar Gillard, Jessica Lakhal-Littleton, Samira Kurinczuk, Jennifer J Nair, Manisha Open Heart Heart Failure and Cardiomyopathies OBJECTIVES: We conducted a systematic review and meta-analysis of studies that compared levels of molecular biomarkers in women with peripartum cardiomyopathy (PPCM) to those in healthy pregnant and postpartum women to: (1) assess the evidence for prolactin (PRL) metabolism in PPCM, (2) ascertain the evidence for biomarkers of iron deficiency in PPCM, (3) identify other biomarkers associated with PPCM. METHODS: We searched Medline, Embase, Cumulated Index to Nursing and Allied Health Literature (CINAHL) and the Global Health Library from inception without language restriction for studies that compared biomarkers levels in PPCM cases to healthy controls. Pooled standardised mean difference (SMD) was generated using a random effects model for the difference in levels of biomarkers. RESULTS: Two studies assessed the association of PRL with PPCM, and reported that PPCM cases have higher levels of total PRL. No studies investigated iron metabolism in PPCM. Other biomarkers associated with PPCM included serum levels of natriuretic peptides (SMD=3.77, 95% CI 0.71 to 6.82), albumin (SMD=-0.67, 95% CI -1.01 to -0.32), C-reactive protein (SMD=1.67, 95% CI 0.22 to 3.12), selenium (SMD=-0.73, 95% CI -1.58 to 0.12), cardiac troponins (SMD=1.06, 95% CI 0.33 to 1.80), creatinine (SMD=0.51, 95% CI 0.33 to 0.69), white bloodcells (SMD=0.44, 95 % CI 0.07 to 0.82), haemoglobin (SMD=-0.45, 95% CI -0.64 to-0.26). CONCLUSIONS: More robust molecular studies are needed to explore the association between prolactin and PPCM in human subjects and to determine the extent to which iron deficiency (with or without anaemia) contributes to the risk of PPCM. BMJ Publishing Group 2020-10-15 /pmc/articles/PMC7566429/ /pubmed/33060142 http://dx.doi.org/10.1136/openhrt-2020-001430 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Heart Failure and Cardiomyopathies Cherubin, Sinaida Peoples, Taylar Gillard, Jessica Lakhal-Littleton, Samira Kurinczuk, Jennifer J Nair, Manisha Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
title | Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
title_full | Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
title_fullStr | Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
title_full_unstemmed | Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
title_short | Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
title_sort | systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
topic | Heart Failure and Cardiomyopathies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566429/ https://www.ncbi.nlm.nih.gov/pubmed/33060142 http://dx.doi.org/10.1136/openhrt-2020-001430 |
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