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In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy

BACKGROUND: CMP-001 is a novel Toll-like receptor-9 agonist that consists of an unmethylated CpG-A motif-rich G10 oligodeoxynucleotide (ODN) encapsulated in virus-like particles. In situ vaccination of CMP-001 is believed to activate local tumor-associated plasmacytoid dendritic cells (pDCs) leading...

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Detalles Bibliográficos
Autores principales:	Cheng, Yinwen, Lemke-Miltner, Caitlin D, Wongpattaraworakul, Wattawan, Wang, Zhaoming, Chan, Carlos H F, Salem, Aliasger K, Weiner, George J, Simons, Andrean L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566437/ https://www.ncbi.nlm.nih.gov/pubmed/33060147 http://dx.doi.org/10.1136/jitc-2020-000940

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