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A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time

We examined changing patterns in cancer incidence and deaths in diabetes compared to the background population. A total of 457,473 patients with type 2 diabetes, included between 1998 and 2014, were matched on age, sex, and county to five controls from the population. Incidence, trends in incidence...

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Autores principales: Bjornsdottir, Hulda Hrund, Rawshani, Araz, Rawshani, Aidin, Franzén, Stefan, Svensson, Ann-Marie, Sattar, Naveed, Gudbjörnsdottir, Soffia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566479/
https://www.ncbi.nlm.nih.gov/pubmed/33060631
http://dx.doi.org/10.1038/s41598-020-73668-y
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author Bjornsdottir, Hulda Hrund
Rawshani, Araz
Rawshani, Aidin
Franzén, Stefan
Svensson, Ann-Marie
Sattar, Naveed
Gudbjörnsdottir, Soffia
author_facet Bjornsdottir, Hulda Hrund
Rawshani, Araz
Rawshani, Aidin
Franzén, Stefan
Svensson, Ann-Marie
Sattar, Naveed
Gudbjörnsdottir, Soffia
author_sort Bjornsdottir, Hulda Hrund
collection PubMed
description We examined changing patterns in cancer incidence and deaths in diabetes compared to the background population. A total of 457,473 patients with type 2 diabetes, included between 1998 and 2014, were matched on age, sex, and county to five controls from the population. Incidence, trends in incidence and post-cancer mortality for cancer were estimated with Cox regression and standardised incidence rates. Causes of death were estimated using logistic regression. Relative importance of risk factors was estimated using Heller’s relative importance model. Type 2 diabetes had a higher risk for all cancer, HR 1.10 (95% CI 1.09–1.12), with highest HRs for liver (3.31), pancreas (2.19) and uterine cancer (1.78). There were lesser increases in risk for breast (1.05) and colorectal cancers (1.20). Type 2 diabetes patients experienced a higher HR 1.23 (1.21–1.25) of overall post-cancer mortality and mortality from prostate, breast, and colorectal cancers. By the year 2030 cancer could become the most common cause of death in type 2 diabetes. Persons with type 2 diabetes are at greater risk of developing cancer and lower chance of surviving it. Notably, hazards for specific cancers (e.g. liver, pancreas) in type 2 patients cannot be explained by obesity alone.
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spelling pubmed-75664792020-10-19 A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time Bjornsdottir, Hulda Hrund Rawshani, Araz Rawshani, Aidin Franzén, Stefan Svensson, Ann-Marie Sattar, Naveed Gudbjörnsdottir, Soffia Sci Rep Article We examined changing patterns in cancer incidence and deaths in diabetes compared to the background population. A total of 457,473 patients with type 2 diabetes, included between 1998 and 2014, were matched on age, sex, and county to five controls from the population. Incidence, trends in incidence and post-cancer mortality for cancer were estimated with Cox regression and standardised incidence rates. Causes of death were estimated using logistic regression. Relative importance of risk factors was estimated using Heller’s relative importance model. Type 2 diabetes had a higher risk for all cancer, HR 1.10 (95% CI 1.09–1.12), with highest HRs for liver (3.31), pancreas (2.19) and uterine cancer (1.78). There were lesser increases in risk for breast (1.05) and colorectal cancers (1.20). Type 2 diabetes patients experienced a higher HR 1.23 (1.21–1.25) of overall post-cancer mortality and mortality from prostate, breast, and colorectal cancers. By the year 2030 cancer could become the most common cause of death in type 2 diabetes. Persons with type 2 diabetes are at greater risk of developing cancer and lower chance of surviving it. Notably, hazards for specific cancers (e.g. liver, pancreas) in type 2 patients cannot be explained by obesity alone. Nature Publishing Group UK 2020-10-15 /pmc/articles/PMC7566479/ /pubmed/33060631 http://dx.doi.org/10.1038/s41598-020-73668-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bjornsdottir, Hulda Hrund
Rawshani, Araz
Rawshani, Aidin
Franzén, Stefan
Svensson, Ann-Marie
Sattar, Naveed
Gudbjörnsdottir, Soffia
A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
title A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
title_full A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
title_fullStr A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
title_full_unstemmed A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
title_short A national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
title_sort national observation study of cancer incidence and mortality risks in type 2 diabetes compared to the background population over time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566479/
https://www.ncbi.nlm.nih.gov/pubmed/33060631
http://dx.doi.org/10.1038/s41598-020-73668-y
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