Multiplex melanoma families are enriched for polygenic risk

Cancers, including cutaneous melanoma, can cluster in families. In addition to environmental etiological factors such as ultraviolet radiation, cutaneous melanoma has a strong genetic component. Genetic risks for cutaneous melanoma range from rare, high-penetrance mutations to common, low-penetrance...

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Detalles Bibliográficos
Autores principales: Law, Matthew H, Aoude, Lauren G, Duffy, David L, Long, Georgina V, Johansson, Peter A, Pritchard, Antonia L, Khosrotehrani, Kiarash, Mann, Graham J, Montgomery, Grant W, Iles, Mark M, Cust, Anne E, Palmer, Jane M, Shannon, Kerwin F, Spillane, Andrew J, Stretch, Jonathan R, Thompson, John F, Saw, Robyn P M, Scolyer, Richard A, Martin, Nicholas G, Hayward, Nicholas K, MacGregor, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Association Studies Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566496/
https://www.ncbi.nlm.nih.gov/pubmed/32716505
http://dx.doi.org/10.1093/hmg/ddaa156

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