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Long-acting antibody ligand mimetics for HER4-selective agonism

Neuregulin protein 1 (NRG1) is a large (> 60–amino-acid) natural peptide ligand for the ErbB protein family members HER3 and HER4. We developed an agonistic antibody modality, termed antibody ligand mimetics (ALM), by incorporating complex ligand agonists such as NRG1 into an antibody scaffold. W...

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Detalles Bibliográficos
Autores principales:	Shan, Lu, Cook, Kimberly M., Haskins, Nantaporn, Omar, Bilal, Jiang, Yu, Garcia, Andrew, Koksal, Adem, Oganesyan, Vaheh, Rosenthal, Kim, Wu, Herren, Dall’Acqua, William F., Damschroder, Melissa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566517/ https://www.ncbi.nlm.nih.gov/pubmed/33057063 http://dx.doi.org/10.1038/s41598-020-74176-9

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