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2′-fluoro-modified pyrimidines enhance affinity of RNA oligonucleotides to HIV-1 reverse transcriptase

Nucleic acid aptamers can be chemically modified to enhance function, but modifying previously selected aptamers can have nontrivial structural and functional consequences. We present a reselection strategy to evaluate the impact of several modifications on preexisting aptamer pools. RNA aptamer lib...

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Detalles Bibliográficos
Autores principales:	Gruenke, Paige R., Alam, Khalid K., Singh, Kamal, Burke, Donald H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566575/ https://www.ncbi.nlm.nih.gov/pubmed/32732393 http://dx.doi.org/10.1261/rna.077008.120

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