Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis

Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of p...

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Autores principales: Genovese, Giovanni, Derlino, Federica, Berti, Emilio, Marzano, Angelo Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566587/
https://www.ncbi.nlm.nih.gov/pubmed/33117178
http://dx.doi.org/10.3389/fphar.2020.583354
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author Genovese, Giovanni
Derlino, Federica
Berti, Emilio
Marzano, Angelo Valerio
author_facet Genovese, Giovanni
Derlino, Federica
Berti, Emilio
Marzano, Angelo Valerio
author_sort Genovese, Giovanni
collection PubMed
description Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis.
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spelling pubmed-75665872020-10-27 Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis Genovese, Giovanni Derlino, Federica Berti, Emilio Marzano, Angelo Valerio Front Pharmacol Pharmacology Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis. Frontiers Media S.A. 2020-10-02 /pmc/articles/PMC7566587/ /pubmed/33117178 http://dx.doi.org/10.3389/fphar.2020.583354 Text en Copyright © 2020 Genovese, Derlino, Berti and Marzano http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Genovese, Giovanni
Derlino, Federica
Berti, Emilio
Marzano, Angelo Valerio
Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
title Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
title_full Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
title_fullStr Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
title_full_unstemmed Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
title_short Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
title_sort treatment of autoimmune bullous diseases during pregnancy and lactation: a review focusing on pemphigus and pemphigoid gestationis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566587/
https://www.ncbi.nlm.nih.gov/pubmed/33117178
http://dx.doi.org/10.3389/fphar.2020.583354
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