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Nna1 gene deficiency triggers Purkinje neuron death by tubulin hyperglutamylation and ER dysfunction

Posttranslational glutamylation/deglutamylation balance in tubulins influences dendritic maturation and neuronal survival of cerebellar Purkinje neurons (PNs). PNs and some additional neuronal types degenerate in several spontaneous, independently occurring Purkinje cell degeneration (pcd) mice feat...

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Detalles Bibliográficos
Autores principales:	Li, Jianxue, Snyder, Evan Y., Tang, Fenny H.F., Pasqualini, Renata, Arap, Wadih, Sidman, Richard L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566705/ https://www.ncbi.nlm.nih.gov/pubmed/33004692 http://dx.doi.org/10.1172/jci.insight.136078

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