Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

The emergence of SARS-CoV-2 has created an international health crisis, and small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development. Mice are refractory to SARS-CoV-2 infection owing to low-affinity binding to the murine angiotensin-convertin...

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Detalles Bibliográficos
Autores principales: Golden, Joseph W., Cline, Curtis R., Zeng, Xiankun, Garrison, Aura R., Carey, Brian D., Mucker, Eric M., White, Lauren E., Shamblin, Joshua D., Brocato, Rebecca L., Liu, Jun, Babka, April M., Rauch, Hypaitia B., Smith, Jeffrey M., Hollidge, Bradley S., Fitzpatrick, Collin, Badger, Catherine V., Hooper, Jay W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566707/
https://www.ncbi.nlm.nih.gov/pubmed/32841215
http://dx.doi.org/10.1172/jci.insight.142032

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