Solving an MHC allele–specific bias in the reported immunopeptidome

Identification of MHC class I–bound peptides by immunopurification of MHC complexes and subsequent analysis by mass spectrometry is crucial for understanding T cell immunology and immunotherapy. Investigation of the steps for the MHC ligand isolation process revealed biases in widely used isolation...

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Detalles Bibliográficos
Autores principales: Klatt, Martin G., Mack, Kyeara N., Bai, Yang, Aretz, Zita E. H., Nathan, Levy I., Mun, Sung Soo, Dao, Tao, Scheinberg, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566711/
https://www.ncbi.nlm.nih.gov/pubmed/32897882
http://dx.doi.org/10.1172/jci.insight.141264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566711/
https://www.ncbi.nlm.nih.gov/pubmed/32897882
http://dx.doi.org/10.1172/jci.insight.141264

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