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Solving an MHC allele–specific bias in the reported immunopeptidome

Identification of MHC class I–bound peptides by immunopurification of MHC complexes and subsequent analysis by mass spectrometry is crucial for understanding T cell immunology and immunotherapy. Investigation of the steps for the MHC ligand isolation process revealed biases in widely used isolation...

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Detalles Bibliográficos
Autores principales:	Klatt, Martin G., Mack, Kyeara N., Bai, Yang, Aretz, Zita E. H., Nathan, Levy I., Mun, Sung Soo, Dao, Tao, Scheinberg, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2020
Materias:	Technical Advance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566711/ https://www.ncbi.nlm.nih.gov/pubmed/32897882 http://dx.doi.org/10.1172/jci.insight.141264

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