CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth

Engineering T cells to express chimeric antigen receptors (CARs) specific for antigens on hematological cancers has yielded remarkable clinical responses, but with solid tumors, benefit has been more limited. This may reflect lack of suitable target antigens, immune evasion mechanisms in malignant c...

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Detalles Bibliográficos
Autores principales: Zhuang, Xiaodong, Maione, Federica, Robinson, Joseph, Bentley, Michael, Kaul, Baksho, Whitworth, Katharine, Jumbu, Neeraj, Jinks, Elizabeth, Bystrom, Jonas, Gabriele, Pietro, Garibaldi, Elisabetta, Delmastro, Elena, Nagy, Zsuzsanna, Gilham, David, Giraudo, Enrico, Bicknell, Roy, Lee, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566713/
https://www.ncbi.nlm.nih.gov/pubmed/33004686
http://dx.doi.org/10.1172/jci.insight.138808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566713/
https://www.ncbi.nlm.nih.gov/pubmed/33004686
http://dx.doi.org/10.1172/jci.insight.138808

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