Pevonedistat, a NEDD8‐activating enzyme inhibitor, induces apoptosis and augments efficacy of chemotherapy and small molecule inhibitors in pre‐clinical models of diffuse large B‐cell lymphoma

We studied the biological activity of pevonedistat, a first‐in‐class NEDD8‐activating enzyme (NAE) inhibitor, in combination with various cytotoxic chemotherapy agents and small molecule inhibitors in lymphoma preclinical models. Pevonedistat induced cell death in activated B‐cell (ABC) diffuse larg...

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Detalles Bibliográficos
Autores principales: Torka, Pallawi, Mavis, Cory, Kothari, Shalin, Belliotti, Sarah, Gu, Juan, Sundaram, Suchitra, Barth, Matthew, Hernandez‐Ilizaliturri, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Haematologic Malignancy ‐ Lymphoid
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566777/
https://www.ncbi.nlm.nih.gov/pubmed/33073261
http://dx.doi.org/10.1002/jha2.2

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