Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection

BACKGROUND: Responsible for the coronavirus disease 2019 pandemic that began in December 2019, severe acute respiratory syndrome coronavirus 2 mainly causes respiratory insult. Few cases were reported of extrapulmonary involvement, many of which were neurologic. CASE SUMMARY: In this case report, we...

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Autores principales: Montaut, Victor, Madigan, Simone, Pugin, Deborah, Clerc, Olivier, Haesler, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566867/
https://www.ncbi.nlm.nih.gov/pubmed/33134942
http://dx.doi.org/10.1097/CCE.0000000000000248
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author Montaut, Victor
Madigan, Simone
Pugin, Deborah
Clerc, Olivier
Haesler, Laurence
author_facet Montaut, Victor
Madigan, Simone
Pugin, Deborah
Clerc, Olivier
Haesler, Laurence
author_sort Montaut, Victor
collection PubMed
description BACKGROUND: Responsible for the coronavirus disease 2019 pandemic that began in December 2019, severe acute respiratory syndrome coronavirus 2 mainly causes respiratory insult. Few cases were reported of extrapulmonary involvement, many of which were neurologic. CASE SUMMARY: In this case report, we present two cases of prolonged coma after weaning off sedation in severe acute respiratory syndrome coronavirus 2 patients with rapid neurologic improvement shortly after high-dose corticosteroid regimen. CONCLUSIONS: We thus hypothesize an inflammatory process being responsible for the prolonged coma. Inflammatory neurologic insult has been described with other coronaviruses. Further studies are needed to determinate the extent and underlying mechanism of neurologic involvement in severe acute respiratory syndrome coronavirus 2 infections.
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spelling pubmed-75668672020-10-29 Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection Montaut, Victor Madigan, Simone Pugin, Deborah Clerc, Olivier Haesler, Laurence Crit Care Explor Case Report BACKGROUND: Responsible for the coronavirus disease 2019 pandemic that began in December 2019, severe acute respiratory syndrome coronavirus 2 mainly causes respiratory insult. Few cases were reported of extrapulmonary involvement, many of which were neurologic. CASE SUMMARY: In this case report, we present two cases of prolonged coma after weaning off sedation in severe acute respiratory syndrome coronavirus 2 patients with rapid neurologic improvement shortly after high-dose corticosteroid regimen. CONCLUSIONS: We thus hypothesize an inflammatory process being responsible for the prolonged coma. Inflammatory neurologic insult has been described with other coronaviruses. Further studies are needed to determinate the extent and underlying mechanism of neurologic involvement in severe acute respiratory syndrome coronavirus 2 infections. Lippincott Williams & Wilkins 2020-10-15 /pmc/articles/PMC7566867/ /pubmed/33134942 http://dx.doi.org/10.1097/CCE.0000000000000248 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Case Report
Montaut, Victor
Madigan, Simone
Pugin, Deborah
Clerc, Olivier
Haesler, Laurence
Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection
title Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection
title_full Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection
title_fullStr Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection
title_full_unstemmed Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection
title_short Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection
title_sort corticosteroid responsive encephalopathy: prolonged coma in patients late in the course of dreadful severe acute respiratory syndrome coronavirus 2 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566867/
https://www.ncbi.nlm.nih.gov/pubmed/33134942
http://dx.doi.org/10.1097/CCE.0000000000000248
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