Cargando…

The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study

Face processing is mediated by a distributed neural network commonly divided into a “core system” and an “extended system.” The core system consists of several, typically right-lateralized brain regions in the occipito-temporal cortex, including the occipital face area (OFA), the fusiform face area...

Descripción completa

Detalles Bibliográficos
Autores principales: Hildesheim, Franziska E., Debus, Isabell, Kessler, Roman, Thome, Ina, Zimmermann, Kristin M., Steinsträter, Olaf, Sommer, Jens, Kamp-Becker, Inge, Stark, Rudolf, Jansen, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566903/
https://www.ncbi.nlm.nih.gov/pubmed/33123034
http://dx.doi.org/10.3389/fpsyg.2020.507199
_version_ 1783596216259444736
author Hildesheim, Franziska E.
Debus, Isabell
Kessler, Roman
Thome, Ina
Zimmermann, Kristin M.
Steinsträter, Olaf
Sommer, Jens
Kamp-Becker, Inge
Stark, Rudolf
Jansen, Andreas
author_facet Hildesheim, Franziska E.
Debus, Isabell
Kessler, Roman
Thome, Ina
Zimmermann, Kristin M.
Steinsträter, Olaf
Sommer, Jens
Kamp-Becker, Inge
Stark, Rudolf
Jansen, Andreas
author_sort Hildesheim, Franziska E.
collection PubMed
description Face processing is mediated by a distributed neural network commonly divided into a “core system” and an “extended system.” The core system consists of several, typically right-lateralized brain regions in the occipito-temporal cortex, including the occipital face area (OFA), the fusiform face area (FFA) and the posterior superior temporal sulcus (pSTS). It was recently proposed that the face processing network is initially bilateral and becomes right-specialized in the course of the development of reading abilities due to the competition between language-related regions in the left occipito-temporal cortex (e.g., the visual word form area, VWFA) and the FFA for common neural resources. In the present pilot study, we assessed the neural face processing network in 12 children (aged 7–9 years) and 10 adults with functional magnetic resonance imaging (fMRI). The hemispheric lateralization of the core face regions was compared between both groups. The study had two goals: First, we aimed to establish an fMRI paradigm suitable for assessing activation in the core system of face processing in young children at the single subject level. Second, we planned to collect data for a power analysis to calculate the necessary group size for a large-scale cross-sectional imaging study assessing the ontogenetic development of the lateralization of the face processing network, with focus on the FFA. It was possible to detect brain activity in the core system of 75% of children at the single subject level. The average scan-to-scan motion of the included children was comparable to adults, ruling out that potential activation differences between groups are caused by unequal motion artifacts. Hemispheric lateralization of the FFA was 0.07 ± 0.48 in children (indicating bilateral activation) and −0.32 ± 0.52 in adults (indicating right-hemispheric dominance). These results thus showed, as expected, a trend for increased lateralization in adults. The estimated effect size for the FFA lateralization difference was d = 0.78 (indicating medium to large effects). An adequately powered follow-up study (sensitivity 0.8) testing developmental changes of FFA lateralization would therefore require the inclusion of 18 children and 26 adults.
format Online
Article
Text
id pubmed-7566903
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-75669032020-10-28 The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study Hildesheim, Franziska E. Debus, Isabell Kessler, Roman Thome, Ina Zimmermann, Kristin M. Steinsträter, Olaf Sommer, Jens Kamp-Becker, Inge Stark, Rudolf Jansen, Andreas Front Psychol Psychology Face processing is mediated by a distributed neural network commonly divided into a “core system” and an “extended system.” The core system consists of several, typically right-lateralized brain regions in the occipito-temporal cortex, including the occipital face area (OFA), the fusiform face area (FFA) and the posterior superior temporal sulcus (pSTS). It was recently proposed that the face processing network is initially bilateral and becomes right-specialized in the course of the development of reading abilities due to the competition between language-related regions in the left occipito-temporal cortex (e.g., the visual word form area, VWFA) and the FFA for common neural resources. In the present pilot study, we assessed the neural face processing network in 12 children (aged 7–9 years) and 10 adults with functional magnetic resonance imaging (fMRI). The hemispheric lateralization of the core face regions was compared between both groups. The study had two goals: First, we aimed to establish an fMRI paradigm suitable for assessing activation in the core system of face processing in young children at the single subject level. Second, we planned to collect data for a power analysis to calculate the necessary group size for a large-scale cross-sectional imaging study assessing the ontogenetic development of the lateralization of the face processing network, with focus on the FFA. It was possible to detect brain activity in the core system of 75% of children at the single subject level. The average scan-to-scan motion of the included children was comparable to adults, ruling out that potential activation differences between groups are caused by unequal motion artifacts. Hemispheric lateralization of the FFA was 0.07 ± 0.48 in children (indicating bilateral activation) and −0.32 ± 0.52 in adults (indicating right-hemispheric dominance). These results thus showed, as expected, a trend for increased lateralization in adults. The estimated effect size for the FFA lateralization difference was d = 0.78 (indicating medium to large effects). An adequately powered follow-up study (sensitivity 0.8) testing developmental changes of FFA lateralization would therefore require the inclusion of 18 children and 26 adults. Frontiers Media S.A. 2020-10-02 /pmc/articles/PMC7566903/ /pubmed/33123034 http://dx.doi.org/10.3389/fpsyg.2020.507199 Text en Copyright © 2020 Hildesheim, Debus, Kessler, Thome, Zimmermann, Steinsträter, Sommer, Kamp-Becker, Stark and Jansen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Hildesheim, Franziska E.
Debus, Isabell
Kessler, Roman
Thome, Ina
Zimmermann, Kristin M.
Steinsträter, Olaf
Sommer, Jens
Kamp-Becker, Inge
Stark, Rudolf
Jansen, Andreas
The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study
title The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study
title_full The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study
title_fullStr The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study
title_full_unstemmed The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study
title_short The Trajectory of Hemispheric Lateralization in the Core System of Face Processing: A Cross-Sectional Functional Magnetic Resonance Imaging Pilot Study
title_sort trajectory of hemispheric lateralization in the core system of face processing: a cross-sectional functional magnetic resonance imaging pilot study
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566903/
https://www.ncbi.nlm.nih.gov/pubmed/33123034
http://dx.doi.org/10.3389/fpsyg.2020.507199
work_keys_str_mv AT hildesheimfranziskae thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT debusisabell thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT kesslerroman thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT thomeina thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT zimmermannkristinm thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT steinstraterolaf thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT sommerjens thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT kampbeckeringe thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT starkrudolf thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT jansenandreas thetrajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT hildesheimfranziskae trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT debusisabell trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT kesslerroman trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT thomeina trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT zimmermannkristinm trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT steinstraterolaf trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT sommerjens trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT kampbeckeringe trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT starkrudolf trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy
AT jansenandreas trajectoryofhemisphericlateralizationinthecoresystemoffaceprocessingacrosssectionalfunctionalmagneticresonanceimagingpilotstudy