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Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics
A simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566912/ https://www.ncbi.nlm.nih.gov/pubmed/33117772 http://dx.doi.org/10.3389/fbioe.2020.00903 |
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author | Yang, Xing Luo, Yuan Li, Sanpeng Xu, Xiuli Bao, Yingxia Yang, Jiaming Ouyang, Defang Fan, Xingxing Gong, Ping Cai, Lintao |
author_facet | Yang, Xing Luo, Yuan Li, Sanpeng Xu, Xiuli Bao, Yingxia Yang, Jiaming Ouyang, Defang Fan, Xingxing Gong, Ping Cai, Lintao |
author_sort | Yang, Xing |
collection | PubMed |
description | A simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and as its core recognition motifs for molecular self-assembly. In addition, the D-glucose transported protein (GLUT), which is one of the important nutrient transporters and is overexpressed in cancer cells. The conjugation of glycosyl further endues the nanoparticle with good biocompatibility and tumor-targeting ability. Taking advantages of both the cancer cell-targeting capability of small molecular prodrug amphiphile CPPG and the AIE aggregates with strong emission, the prepared CPPG AIE dots can target cancer cells specifically and inhibit the proliferation of cancer cells with good biocompatibility and photostability. Based on the general approach, types of universal organic fluorescent nanoprobes could be facilely constructed for imaging applications and biological therapeutics, which possess the properties of specific recognition and high brightness. |
format | Online Article Text |
id | pubmed-7566912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75669122020-10-27 Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics Yang, Xing Luo, Yuan Li, Sanpeng Xu, Xiuli Bao, Yingxia Yang, Jiaming Ouyang, Defang Fan, Xingxing Gong, Ping Cai, Lintao Front Bioeng Biotechnol Bioengineering and Biotechnology A simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and as its core recognition motifs for molecular self-assembly. In addition, the D-glucose transported protein (GLUT), which is one of the important nutrient transporters and is overexpressed in cancer cells. The conjugation of glycosyl further endues the nanoparticle with good biocompatibility and tumor-targeting ability. Taking advantages of both the cancer cell-targeting capability of small molecular prodrug amphiphile CPPG and the AIE aggregates with strong emission, the prepared CPPG AIE dots can target cancer cells specifically and inhibit the proliferation of cancer cells with good biocompatibility and photostability. Based on the general approach, types of universal organic fluorescent nanoprobes could be facilely constructed for imaging applications and biological therapeutics, which possess the properties of specific recognition and high brightness. Frontiers Media S.A. 2020-10-02 /pmc/articles/PMC7566912/ /pubmed/33117772 http://dx.doi.org/10.3389/fbioe.2020.00903 Text en Copyright © 2020 Yang, Luo, Li, Xu, Bao, Yang, Ouyang, Fan, Gong and Cai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Yang, Xing Luo, Yuan Li, Sanpeng Xu, Xiuli Bao, Yingxia Yang, Jiaming Ouyang, Defang Fan, Xingxing Gong, Ping Cai, Lintao Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title | Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_full | Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_fullStr | Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_full_unstemmed | Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_short | Small Molecular Prodrug Amphiphile Self-Assembled AIE Dots for Cancer Theranostics |
title_sort | small molecular prodrug amphiphile self-assembled aie dots for cancer theranostics |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566912/ https://www.ncbi.nlm.nih.gov/pubmed/33117772 http://dx.doi.org/10.3389/fbioe.2020.00903 |
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