Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient

RAS signaling is a promising target for colorectal cancer (CRC) therapy, and a variety of selective inhibitors have been developed. However, their use has often failed to demonstrate a significant benefit in CRC patients. Here, we used patient-derived organoids (PDOs) derived from a familial adenoma...

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Detalles Bibliográficos
Autores principales: Osumi, Hiroki, Muroi, Atsushi, Sakahara, Mizuho, Kawachi, Hiroshi, Okamoto, Takuya, Natsume, Yasuko, Yamanaka, Hitomi, Takano, Hiroshi, Kusama, Daisuke, Shinozaki, Eiji, Ooki, Akira, Yamaguchi, Kensei, Ueno, Masashi, Takeuchi, Kengo, Noda, Tetsuo, Nagayama, Satoshi, Koshikawa, Naohiko, Yao, Ryoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567075/
https://www.ncbi.nlm.nih.gov/pubmed/33060766
http://dx.doi.org/10.1038/s41598-020-74530-x

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