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Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease

The relationship between changes in body components and the risk of nonalcoholic fatty liver disease (NAFLD) is not fully understood. We investigated the effects of body components and subsequent changes on incident NAFLD at follow-up ultrasound scanning in a longitudinal cohort. We included 9967 pa...

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Autores principales: Kim, Hwi Young, Baik, Su Jung, Lee, Hye Ah, Lee, Byoung Kwon, Lee, Hye Sun, Kim, Tae Hun, Yoo, Kwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567080/
https://www.ncbi.nlm.nih.gov/pubmed/33060775
http://dx.doi.org/10.1038/s41598-020-74659-9
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author Kim, Hwi Young
Baik, Su Jung
Lee, Hye Ah
Lee, Byoung Kwon
Lee, Hye Sun
Kim, Tae Hun
Yoo, Kwon
author_facet Kim, Hwi Young
Baik, Su Jung
Lee, Hye Ah
Lee, Byoung Kwon
Lee, Hye Sun
Kim, Tae Hun
Yoo, Kwon
author_sort Kim, Hwi Young
collection PubMed
description The relationship between changes in body components and the risk of nonalcoholic fatty liver disease (NAFLD) is not fully understood. We investigated the effects of body components and subsequent changes on incident NAFLD at follow-up ultrasound scanning in a longitudinal cohort. We included 9967 participants without NAFLD at baseline who underwent serial health examinations. Sex-specific, weight-adjusted skeletal muscle index (SMI(_Wt)) was used. Mean follow-up duration was 48.5 ± 33.5 months. NAFLD developed in 2395 participants (24.0%). Body composition was measured using bioelectrical impedance analysis. The following baseline body components were significantly associated with incident NAFLD: the lowest and middle SMI(_Wt) tertiles in the normal-weight group (adjusted hazard ratio [aHR] = 2.20 and 1.54, respectively), and fat percentage in the normal-weight (aHR = 1.12), overweight (aHR = 1.05), and obese groups (aHR = 1.03) (all P < 0.05). Among 5,033 participants who underwent ≥ 3 health examinations, SMI(_Wt) increase between the first and second examinations was an independent protective factor against incident NAFLD in non-obese groups (P < 0.05). Increased fat percentage was an independent risk factor for incident NAFLD in all weight categories (P < 0.05). High fat mass at baseline may be a better predictor of incident NAFLD than muscle mass. Reciprocal changes in fat and muscle mass during the first year of follow-up predicted incident NAFLD in non-obese groups.
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spelling pubmed-75670802020-10-19 Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease Kim, Hwi Young Baik, Su Jung Lee, Hye Ah Lee, Byoung Kwon Lee, Hye Sun Kim, Tae Hun Yoo, Kwon Sci Rep Article The relationship between changes in body components and the risk of nonalcoholic fatty liver disease (NAFLD) is not fully understood. We investigated the effects of body components and subsequent changes on incident NAFLD at follow-up ultrasound scanning in a longitudinal cohort. We included 9967 participants without NAFLD at baseline who underwent serial health examinations. Sex-specific, weight-adjusted skeletal muscle index (SMI(_Wt)) was used. Mean follow-up duration was 48.5 ± 33.5 months. NAFLD developed in 2395 participants (24.0%). Body composition was measured using bioelectrical impedance analysis. The following baseline body components were significantly associated with incident NAFLD: the lowest and middle SMI(_Wt) tertiles in the normal-weight group (adjusted hazard ratio [aHR] = 2.20 and 1.54, respectively), and fat percentage in the normal-weight (aHR = 1.12), overweight (aHR = 1.05), and obese groups (aHR = 1.03) (all P < 0.05). Among 5,033 participants who underwent ≥ 3 health examinations, SMI(_Wt) increase between the first and second examinations was an independent protective factor against incident NAFLD in non-obese groups (P < 0.05). Increased fat percentage was an independent risk factor for incident NAFLD in all weight categories (P < 0.05). High fat mass at baseline may be a better predictor of incident NAFLD than muscle mass. Reciprocal changes in fat and muscle mass during the first year of follow-up predicted incident NAFLD in non-obese groups. Nature Publishing Group UK 2020-10-15 /pmc/articles/PMC7567080/ /pubmed/33060775 http://dx.doi.org/10.1038/s41598-020-74659-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Hwi Young
Baik, Su Jung
Lee, Hye Ah
Lee, Byoung Kwon
Lee, Hye Sun
Kim, Tae Hun
Yoo, Kwon
Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
title Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
title_full Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
title_fullStr Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
title_full_unstemmed Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
title_short Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
title_sort relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567080/
https://www.ncbi.nlm.nih.gov/pubmed/33060775
http://dx.doi.org/10.1038/s41598-020-74659-9
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