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Immortalization of human hepatocytes from biliary atresia with CDK4(R24C), cyclin D1, and TERT for cytochrome P450 induction testing

Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from a liver associated with biliary atresia. Hepato...

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Detalles Bibliográficos
Autores principales:	Nishiwaki, Manami, Toyoda, Masashi, Oishi, Yoshie, Ishida, Seiichi, Horiuchi, Shin-ichiro, Makino-Itou, Hatsune, Kimura, Tohru, Ohno, Shin-ichi, Ohkura, Takashi, Enosawa, Shin, Akutsu, Hidenori, Nakazawa, Atsuko, Kasahara, Mureo, Kiyono, Tohru, Umezawa, Akihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567112/ https://www.ncbi.nlm.nih.gov/pubmed/33060611 http://dx.doi.org/10.1038/s41598-020-73992-3

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