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Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by chronic polyarthritis. Many types of cells play pivotal roles in the pathogenicity of RA, such as T cells, B cells, macrophages, dendritic cells (DCs), osteoclasts (OCs), and fibroblast-like synoviocytes (FLS). Tripterygium w...

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Autores principales: Tang, Yujun, Liu, Qiuping, Feng, Yuxiang, Zhang, Yi, Xu, Zhenghao, Wen, Chengping, Zhang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567162/
https://www.ncbi.nlm.nih.gov/pubmed/33123015
http://dx.doi.org/10.3389/fphar.2020.583171
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author Tang, Yujun
Liu, Qiuping
Feng, Yuxiang
Zhang, Yi
Xu, Zhenghao
Wen, Chengping
Zhang, Yun
author_facet Tang, Yujun
Liu, Qiuping
Feng, Yuxiang
Zhang, Yi
Xu, Zhenghao
Wen, Chengping
Zhang, Yun
author_sort Tang, Yujun
collection PubMed
description Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by chronic polyarthritis. Many types of cells play pivotal roles in the pathogenicity of RA, such as T cells, B cells, macrophages, dendritic cells (DCs), osteoclasts (OCs), and fibroblast-like synoviocytes (FLS). Tripterygium wilfordii Hook f. (TwHf) and its ingredients are able to control disease activity by regulating the functions of cells mentioned above, and the clinical studies have highlighted the importance of TwHf ingredients in RA treatment. They have been demonstrated to improve the RA symptoms of animal models and patients. In this review, we discussed the effect of TwHf ingredients on pathogenicity cells, including disease/cell phenotypes and molecular mechanisms. Here, we constructed a cell-cell interaction network to visualize the effect of TwHf ingredients. We found that TwHf ingredients could inhibit the differentiation and proliferation of the pathogenicity cells. Besides, the components could decrease the levels of pathogenicity cytokines [i.e., interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α)]. Many signaling pathways are involved in the underlying mechanisms, such as PI3K, NF-κB, and MAPK signaling pathways.
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spelling pubmed-75671622020-10-28 Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis Tang, Yujun Liu, Qiuping Feng, Yuxiang Zhang, Yi Xu, Zhenghao Wen, Chengping Zhang, Yun Front Pharmacol Pharmacology Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by chronic polyarthritis. Many types of cells play pivotal roles in the pathogenicity of RA, such as T cells, B cells, macrophages, dendritic cells (DCs), osteoclasts (OCs), and fibroblast-like synoviocytes (FLS). Tripterygium wilfordii Hook f. (TwHf) and its ingredients are able to control disease activity by regulating the functions of cells mentioned above, and the clinical studies have highlighted the importance of TwHf ingredients in RA treatment. They have been demonstrated to improve the RA symptoms of animal models and patients. In this review, we discussed the effect of TwHf ingredients on pathogenicity cells, including disease/cell phenotypes and molecular mechanisms. Here, we constructed a cell-cell interaction network to visualize the effect of TwHf ingredients. We found that TwHf ingredients could inhibit the differentiation and proliferation of the pathogenicity cells. Besides, the components could decrease the levels of pathogenicity cytokines [i.e., interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α)]. Many signaling pathways are involved in the underlying mechanisms, such as PI3K, NF-κB, and MAPK signaling pathways. Frontiers Media S.A. 2020-10-02 /pmc/articles/PMC7567162/ /pubmed/33123015 http://dx.doi.org/10.3389/fphar.2020.583171 Text en Copyright © 2020 Tang, Liu, Feng, Zhang, Xu, Wen and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Tang, Yujun
Liu, Qiuping
Feng, Yuxiang
Zhang, Yi
Xu, Zhenghao
Wen, Chengping
Zhang, Yun
Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis
title Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis
title_full Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis
title_fullStr Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis
title_full_unstemmed Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis
title_short Tripterygium Ingredients for Pathogenicity Cells in Rheumatoid Arthritis
title_sort tripterygium ingredients for pathogenicity cells in rheumatoid arthritis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567162/
https://www.ncbi.nlm.nih.gov/pubmed/33123015
http://dx.doi.org/10.3389/fphar.2020.583171
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