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H-FABP: A beacon of hope for prediabetic heart disease

BACKGROUND: Prediabetes is increasingly being studied in the context of its association with cardiovascular disease (CVD). Besides raised HbA1c and sugar levels, the major underlying defect seems to be insulin resistance (IR). Subclinical atherosclerosis, measured by high sensitivity C reactive prot...

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Autores principales: Ramesh, Priyamvadha, Chauhan, Ajay, Goyal, Parul, Singh, Akanksha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567222/
https://www.ncbi.nlm.nih.gov/pubmed/33102307
http://dx.doi.org/10.4103/jfmpc.jfmpc_296_20
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author Ramesh, Priyamvadha
Chauhan, Ajay
Goyal, Parul
Singh, Akanksha
author_facet Ramesh, Priyamvadha
Chauhan, Ajay
Goyal, Parul
Singh, Akanksha
author_sort Ramesh, Priyamvadha
collection PubMed
description BACKGROUND: Prediabetes is increasingly being studied in the context of its association with cardiovascular disease (CVD). Besides raised HbA1c and sugar levels, the major underlying defect seems to be insulin resistance (IR). Subclinical atherosclerosis, measured by high sensitivity C reactive protein (hsCRP) and carotid artery intima media thickness (CIMT) underlies the pathogenesis of CVD in prediabetes. Heart-type fatty acid binding protein (H-FABP), a novel cardiac biomarker also might have a role in predictin prediabetic heart disease. AIMS: The aim of the study is to compare serum levels of H-FABP in prediabetics and controls and correlate them with the atherosclerotic markers, hsCRP and CIMT. SETTING AND DESIGN: 50 prediabetic patients and 50 age, sex and BMI matched controls were employed in the case control study. Serum F & PPBS, (HbA1c), fasting insulin levels were measured in cases and controls. Serum H-FABP was measured in both cases and controls. All cases and controls were subjected to bilateral CIMT measurements and Serum hsCRP levels. The values were compared between both the groups and subjected to appropriate statistical analysis. STATISTICAL ANALYSIS USED: Categorical variables were presented in number and percentage (%) and continuous variables were presented as mean ± SD and median. Normality of data was tested by Kolmogorov-Smirnov test. If the normality was rejected then non parametric test was used. Quantitative variables were compared using Independent t test/Mann-Whitney Test (when the data sets were not normally distributed) between the two groups. Qualitative variables were correlated using Chi-Square test/Fisher's Exact test. Spearman rank correlation coefficient was used to find out the correlation of various parameters with each other. Univariate linear regression was used to find out the cause and effect relationship between various parameters. A p <0.05 was considered statistically significant. The data analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. RESULTS: The mean serum levels of H-FABP among cases and controls were 6.38± 2.76ng/ml and 3.24 ± 2.47 ng/ml respectively (p <0.0001). Mean CIMT was found to be higher in prediabetics (0.59 ± 0.11 mm ) compared to controls (0.45 ± 0.07mm) (p<0.0001). Serum hsCRP levels were also statistically higher in prediabetics (5.75± 4.16 mg/l) then that of controls (1.86± 1.67 mg/l) (p <0.0001). The correlations of the two variables, hsCRP and CIMT with H-FABP were both strongly positive (r = 0.687) & (r = 0.779) respectively [both cases (p < 0.0001)]. CONCLUSION: The novel cardiac biomarker H-FAPB might be a good predictor of cardiovascular risks in prediabetics.
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spelling pubmed-75672222020-10-22 H-FABP: A beacon of hope for prediabetic heart disease Ramesh, Priyamvadha Chauhan, Ajay Goyal, Parul Singh, Akanksha J Family Med Prim Care Original Article BACKGROUND: Prediabetes is increasingly being studied in the context of its association with cardiovascular disease (CVD). Besides raised HbA1c and sugar levels, the major underlying defect seems to be insulin resistance (IR). Subclinical atherosclerosis, measured by high sensitivity C reactive protein (hsCRP) and carotid artery intima media thickness (CIMT) underlies the pathogenesis of CVD in prediabetes. Heart-type fatty acid binding protein (H-FABP), a novel cardiac biomarker also might have a role in predictin prediabetic heart disease. AIMS: The aim of the study is to compare serum levels of H-FABP in prediabetics and controls and correlate them with the atherosclerotic markers, hsCRP and CIMT. SETTING AND DESIGN: 50 prediabetic patients and 50 age, sex and BMI matched controls were employed in the case control study. Serum F & PPBS, (HbA1c), fasting insulin levels were measured in cases and controls. Serum H-FABP was measured in both cases and controls. All cases and controls were subjected to bilateral CIMT measurements and Serum hsCRP levels. The values were compared between both the groups and subjected to appropriate statistical analysis. STATISTICAL ANALYSIS USED: Categorical variables were presented in number and percentage (%) and continuous variables were presented as mean ± SD and median. Normality of data was tested by Kolmogorov-Smirnov test. If the normality was rejected then non parametric test was used. Quantitative variables were compared using Independent t test/Mann-Whitney Test (when the data sets were not normally distributed) between the two groups. Qualitative variables were correlated using Chi-Square test/Fisher's Exact test. Spearman rank correlation coefficient was used to find out the correlation of various parameters with each other. Univariate linear regression was used to find out the cause and effect relationship between various parameters. A p <0.05 was considered statistically significant. The data analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. RESULTS: The mean serum levels of H-FABP among cases and controls were 6.38± 2.76ng/ml and 3.24 ± 2.47 ng/ml respectively (p <0.0001). Mean CIMT was found to be higher in prediabetics (0.59 ± 0.11 mm ) compared to controls (0.45 ± 0.07mm) (p<0.0001). Serum hsCRP levels were also statistically higher in prediabetics (5.75± 4.16 mg/l) then that of controls (1.86± 1.67 mg/l) (p <0.0001). The correlations of the two variables, hsCRP and CIMT with H-FABP were both strongly positive (r = 0.687) & (r = 0.779) respectively [both cases (p < 0.0001)]. CONCLUSION: The novel cardiac biomarker H-FAPB might be a good predictor of cardiovascular risks in prediabetics. Wolters Kluwer - Medknow 2020-07-30 /pmc/articles/PMC7567222/ /pubmed/33102307 http://dx.doi.org/10.4103/jfmpc.jfmpc_296_20 Text en Copyright: © 2020 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ramesh, Priyamvadha
Chauhan, Ajay
Goyal, Parul
Singh, Akanksha
H-FABP: A beacon of hope for prediabetic heart disease
title H-FABP: A beacon of hope for prediabetic heart disease
title_full H-FABP: A beacon of hope for prediabetic heart disease
title_fullStr H-FABP: A beacon of hope for prediabetic heart disease
title_full_unstemmed H-FABP: A beacon of hope for prediabetic heart disease
title_short H-FABP: A beacon of hope for prediabetic heart disease
title_sort h-fabp: a beacon of hope for prediabetic heart disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567222/
https://www.ncbi.nlm.nih.gov/pubmed/33102307
http://dx.doi.org/10.4103/jfmpc.jfmpc_296_20
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