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The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man

Hemophagocytic lymphohistiocytosis (HLH) is a rare, poorly recognized and underdiagnosed syndrome of excessive immune activation, which is rapidly fatal. HLH can occur as a familial or secondary disorder. Secondary HLH is most commonly associated with infections, malignancies, or autoimmune diseases...

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Autores principales: Singh, Akanksha, Chauhan, Ajay, Padole, Vaibhav, Chhabra, Devyani, Upneja, Raghav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567245/
https://www.ncbi.nlm.nih.gov/pubmed/33102367
http://dx.doi.org/10.4103/jfmpc.jfmpc_274_20
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author Singh, Akanksha
Chauhan, Ajay
Padole, Vaibhav
Chhabra, Devyani
Upneja, Raghav
author_facet Singh, Akanksha
Chauhan, Ajay
Padole, Vaibhav
Chhabra, Devyani
Upneja, Raghav
author_sort Singh, Akanksha
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) is a rare, poorly recognized and underdiagnosed syndrome of excessive immune activation, which is rapidly fatal. HLH can occur as a familial or secondary disorder. Secondary HLH is most commonly associated with infections, malignancies, or autoimmune diseases. It primarily affects patients with a compromised immune system and rarely presents in immunocompetent individuals. Acute cytomegalovirus (CMV) associated HLH in the immunocompetent individual is extremely rare and only documented in five case reports till date. We, hereby, report a case of 18 years old young immunocompetent man who was diagnosed to have HLH secondary to CMV infection.
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spelling pubmed-75672452020-10-22 The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man Singh, Akanksha Chauhan, Ajay Padole, Vaibhav Chhabra, Devyani Upneja, Raghav J Family Med Prim Care Case Report Hemophagocytic lymphohistiocytosis (HLH) is a rare, poorly recognized and underdiagnosed syndrome of excessive immune activation, which is rapidly fatal. HLH can occur as a familial or secondary disorder. Secondary HLH is most commonly associated with infections, malignancies, or autoimmune diseases. It primarily affects patients with a compromised immune system and rarely presents in immunocompetent individuals. Acute cytomegalovirus (CMV) associated HLH in the immunocompetent individual is extremely rare and only documented in five case reports till date. We, hereby, report a case of 18 years old young immunocompetent man who was diagnosed to have HLH secondary to CMV infection. Wolters Kluwer - Medknow 2020-07-30 /pmc/articles/PMC7567245/ /pubmed/33102367 http://dx.doi.org/10.4103/jfmpc.jfmpc_274_20 Text en Copyright: © 2020 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Singh, Akanksha
Chauhan, Ajay
Padole, Vaibhav
Chhabra, Devyani
Upneja, Raghav
The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man
title The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man
title_full The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man
title_fullStr The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man
title_full_unstemmed The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man
title_short The great masquerader: Hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man
title_sort great masquerader: hemophagocytic lymphohistiocytosis secondary to cytomegalovirus infection in an immunocompetent young man
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567245/
https://www.ncbi.nlm.nih.gov/pubmed/33102367
http://dx.doi.org/10.4103/jfmpc.jfmpc_274_20
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