Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma

Medulloblastoma (MB), the most common form of pediatric brain malignancy, has a low frequency of oncogenic mutations but pronouncedly abnormal DNA methylation changes. Epigenetic analysis of circulating cell-free tumor DNA (ctDNA) by liquid biopsy offers an approach for real-time monitoring of tumor...

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Detalles Bibliográficos
Autores principales: Li, Jia, Zhao, Sibo, Lee, Minjung, Yin, Yue, Li, Jin, Zhou, Yubin, Ballester, Leomar Y., Esquenazi, Yoshua, Dashwood, Roderick H., Davies, Peter J. A., Parsons, D. Williams, Li, Xiao-Nan, Huang, Yun, Sun, Deqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567591/
https://www.ncbi.nlm.nih.gov/pubmed/33067228
http://dx.doi.org/10.1126/sciadv.abb5427

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