The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type 1 diabetes (T1D) but is also recognized by CD8(+) T cells from healthy individuals. We quantified PPI-specific CD8(+) T cells within different areas of the human pancreas from nondiabetic controls, autoantibody...

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Detalles Bibliográficos
Autores principales: Bender, Christine, Rodriguez-Calvo, Teresa, Amirian, Natalie, Coppieters, Ken T., von Herrath, Matthias G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567597/
https://www.ncbi.nlm.nih.gov/pubmed/33067232
http://dx.doi.org/10.1126/sciadv.abc5586

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