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Increased RNA editing in maternal immune activation model of neurodevelopmental disease
The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567798/ https://www.ncbi.nlm.nih.gov/pubmed/33067431 http://dx.doi.org/10.1038/s41467-020-19048-6 |
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author | Tsivion-Visbord, Hadas Kopel, Eli Feiglin, Ariel Sofer, Tamar Barzilay, Ran Ben-Zur, Tali Yaron, Orly Offen, Daniel Levanon, Erez Y. |
author_facet | Tsivion-Visbord, Hadas Kopel, Eli Feiglin, Ariel Sofer, Tamar Barzilay, Ran Ben-Zur, Tali Yaron, Orly Offen, Daniel Levanon, Erez Y. |
author_sort | Tsivion-Visbord, Hadas |
collection | PubMed |
description | The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the viral mimic PolyI:C infection during early gestation. We investigated the transcriptional changes in the brains of mouse fetuses following MIA during the prenatal period, and evaluated the behavioral and biochemical changes in the adult brain. The results reveal an increase in RNA editing levels and dysregulation in brain development-related gene pathways in the fetal brains of MIA mice. These MIA-induced brain editing changes are not observed in adulthood, although MIA-induced behavioral deficits are observed. Taken together, our findings suggest that MIA induces transient dysregulation of RNA editing at a critical time in brain development. |
format | Online Article Text |
id | pubmed-7567798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75677982020-10-19 Increased RNA editing in maternal immune activation model of neurodevelopmental disease Tsivion-Visbord, Hadas Kopel, Eli Feiglin, Ariel Sofer, Tamar Barzilay, Ran Ben-Zur, Tali Yaron, Orly Offen, Daniel Levanon, Erez Y. Nat Commun Article The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the viral mimic PolyI:C infection during early gestation. We investigated the transcriptional changes in the brains of mouse fetuses following MIA during the prenatal period, and evaluated the behavioral and biochemical changes in the adult brain. The results reveal an increase in RNA editing levels and dysregulation in brain development-related gene pathways in the fetal brains of MIA mice. These MIA-induced brain editing changes are not observed in adulthood, although MIA-induced behavioral deficits are observed. Taken together, our findings suggest that MIA induces transient dysregulation of RNA editing at a critical time in brain development. Nature Publishing Group UK 2020-10-16 /pmc/articles/PMC7567798/ /pubmed/33067431 http://dx.doi.org/10.1038/s41467-020-19048-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tsivion-Visbord, Hadas Kopel, Eli Feiglin, Ariel Sofer, Tamar Barzilay, Ran Ben-Zur, Tali Yaron, Orly Offen, Daniel Levanon, Erez Y. Increased RNA editing in maternal immune activation model of neurodevelopmental disease |
title | Increased RNA editing in maternal immune activation model of neurodevelopmental disease |
title_full | Increased RNA editing in maternal immune activation model of neurodevelopmental disease |
title_fullStr | Increased RNA editing in maternal immune activation model of neurodevelopmental disease |
title_full_unstemmed | Increased RNA editing in maternal immune activation model of neurodevelopmental disease |
title_short | Increased RNA editing in maternal immune activation model of neurodevelopmental disease |
title_sort | increased rna editing in maternal immune activation model of neurodevelopmental disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567798/ https://www.ncbi.nlm.nih.gov/pubmed/33067431 http://dx.doi.org/10.1038/s41467-020-19048-6 |
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