Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Patients with type 2 diabetes (T2D) have a lower risk of Mycobacterium tuberculosis infection, progression from infection to tuberculosis (TB) disease, TB morality and TB recurrence, when being treated with metformin. However, a detailed mechanistic understanding of these protective effects is lacki...

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Detalles Bibliográficos
Autores principales: Böhme, Julia, Martinez, Nuria, Li, Shamin, Lee, Andrea, Marzuki, Mardiana, Tizazu, Anteneh Mehari, Ackart, David, Frenkel, Jessica Haugen, Todd, Alexandra, Lachmandas, Ekta, Lum, Josephine, Shihui, Foo, Ng, Tze Pin, Lee, Bernett, Larbi, Anis, Netea, Mihai G., Basaraba, Randall, van Crevel, Reinout, Newell, Evan, Kornfeld, Hardy, Singhal, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567856/
https://www.ncbi.nlm.nih.gov/pubmed/33067434
http://dx.doi.org/10.1038/s41467-020-19095-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567856/
https://www.ncbi.nlm.nih.gov/pubmed/33067434
http://dx.doi.org/10.1038/s41467-020-19095-z

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