SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells

SPARC-deficient mice have been shown to exhibit impaired glucose tolerance and insulin secretion, but the underlying mechanism remains unknown. Here, we showed that SPARC enhanced the promoting effect of Muscarinic receptor agonist oxotremorine-M on insulin secretion in cultured mouse islets. Overex...

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Detalles Bibliográficos
Autores principales: Hu, Li, He, Fengli, Huang, Meifeng, Zhao, Qian, Cheng, Lamei, Said, Neveen, Zhou, Zhiguang, Liu, Feng, Dai, Yan-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567887/
https://www.ncbi.nlm.nih.gov/pubmed/33067534
http://dx.doi.org/10.1038/s41598-020-74593-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567887/
https://www.ncbi.nlm.nih.gov/pubmed/33067534
http://dx.doi.org/10.1038/s41598-020-74593-w

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