Cargando…

SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells

SPARC-deficient mice have been shown to exhibit impaired glucose tolerance and insulin secretion, but the underlying mechanism remains unknown. Here, we showed that SPARC enhanced the promoting effect of Muscarinic receptor agonist oxotremorine-M on insulin secretion in cultured mouse islets. Overex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Li, He, Fengli, Huang, Meifeng, Zhao, Qian, Cheng, Lamei, Said, Neveen, Zhou, Zhiguang, Liu, Feng, Dai, Yan-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567887/ https://www.ncbi.nlm.nih.gov/pubmed/33067534 http://dx.doi.org/10.1038/s41598-020-74593-w

Ejemplares similares

Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells
por: Luo, Yan, et al.
Publicado: (2014)

Roles of SPARC in urothelial carcinogenesis, progression and metastasis
por: Said, Neveen
Publicado: (2016)

A Role for SPARC in the Moderation of Human Insulin Secretion
por: Harries, Lorna W., et al.
Publicado: (2013)

The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets
por: Vivot, Kevin, et al.
Publicado: (2016)

SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieu
por: Pan, Kehua, et al.
Publicado: (2021)

SPARC Inhibits Metabolic Plasticity in Ovarian Cancer
por: Naczki, Christine, et al.
Publicado: (2018)

SPARC Fusion Protein Induces Cellular Adhesive Signaling
por: Cheng, Lamei, et al.
Publicado: (2013)

Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC
por: John, Bincy, et al.
Publicado: (2019)

Platelet‐derived lipids promote insulin secretion of pancreatic β cells
por: Karwen, Till, et al.
Publicado: (2023)

Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer
por: Gao, Jun, et al.
Publicado: (2010)

Cholesterol Sulfate Exerts Protective Effect on Pancreatic β-Cells by Regulating β-Cell Mass and Insulin Secretion
por: Zhang, Xueping, et al.
Publicado: (2022)

Insulin secretion hot spots in pancreatic β cells as secreting adhesions
por: Fye, Margret A., et al.
Publicado: (2023)

Optogenetic regulation of insulin secretion in pancreatic β-cells
por: Zhang, Fan, et al.
Publicado: (2017)

Secreted Protein Acidic and Rich in Cysteine (SPARC) Suppresses Angiogenesis by Down-Regulating the Expression of VEGF and MMP-7 in Gastric Cancer
por: Zhang, Jun-Ling, et al.
Publicado: (2012)

Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion
por: Munakata, Yuichiro, et al.
Publicado: (2018)

RGS4-Deficiency Alters Intracellular Calcium and PKA-Mediated Control of Insulin Secretion in Glucose-Stimulated Beta Islets
por: Bastin, Guillaume, et al.
Publicado: (2021)

Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3
por: Ding, Weifeng, et al.
Publicado: (2018)

SAT061 Deficiency Of ENaC Excites Pancreatic β Cells To Promote Insulin Secretion
por: Que, Yanting, et al.
Publicado: (2023)

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells
por: MacDonald, Patrick E, et al.
Publicado: (2006)

The effect of unhealthy β-cells on insulin secretion in pancreatic islets
por: Pu, Yang, et al.
Publicado: (2013)

Neuronatin regulates pancreatic β cell insulin content and secretion
por: Millership, Steven J., et al.
Publicado: (2018)

SPARC's Initiative
por: Alison Buckholtz
Publicado: (2002)

SPARC: A Potential Prognostic and Therapeutic Target in Pancreatic Cancer
por: Vaz, Juan, et al.
Publicado: (2015)

Eight RGS and RGS-like Proteins Orchestrate Growth, Differentiation, and Pathogenicity of Magnaporthe oryzae
por: Zhang, Haifeng, et al.
Publicado: (2011)

TRP-ing Down the Path to Insulin Secretion
por: MacDonald, Patrick E.
Publicado: (2011)

RGS5 promotes arterial growth during arteriogenesis
por: Arnold, Caroline, et al.
Publicado: (2014)

Correction: Eight RGS and RGS-like Proteins Orchestrate Growth, Differentiation, and Pathogenicity of Magnaporthe oryzae
por: Zhang, Haifeng, et al.
Publicado: (2019)

Modeling of the gap junction of pancreatic β-cells and the robustness of insulin secretion
por: Kitagawa, Tomoki, et al.
Publicado: (2010)

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
por: Fulgenzi, Gianluca, et al.
Publicado: (2020)

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity
por: Rivera, Lee B., et al.
Publicado: (2011)

The SPARC complex defines RNAPII promoters in Trypanosoma brucei
por: Staneva, Desislava P, et al.
Publicado: (2022)

Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose
por: Kos, Katrina, et al.
Publicado: (2009)

Pax6 interacts with SPARC and TGF-β in murine eyes
por: Shubham, Kumar, et al.
Publicado: (2012)

Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales
por: Schäper, Simon, et al.
Publicado: (2018)

Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer
por: Chang, Chih-Hau, et al.
Publicado: (2017)

Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice
por: Ghanemi, Abdelaziz, et al.
Publicado: (2022)

Deregulation of RGS17 Expression Promotes Breast Cancer Progression
por: Li, Yuhua, et al.
Publicado: (2015)

Characteristics of a Regulator of G-Protein Signaling (RGS) rgsC in Aspergillus fumigatus
por: Kim, Young, et al.
Publicado: (2017)

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4
por: Borges, Jordana I., et al.
Publicado: (2023)

Nitric oxide interacts with cholinoceptors to modulate insulin secretion by pancreatic β cells
por: Mussa, Bashair M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kqipkr9qf5uga5r6mgbgbkh8gu