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Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages

Macrophages play an essential role in the early immune response against Toxoplasma and are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits a variety of anti-Toxoplasma activities in macrophages. Using a genome-wide CRISPR screen we identify 353 Toxoplas...

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Detalles Bibliográficos
Autores principales:	Wang, Yifan, Sangaré, Lamba Omar, Paredes-Santos, Tatiana C., Hassan, Musa A., Krishnamurthy, Shruthi, Furuta, Anna M., Markus, Benedikt M., Lourido, Sebastian, Saeij, Jeroen P. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567896/ https://www.ncbi.nlm.nih.gov/pubmed/33067458 http://dx.doi.org/10.1038/s41467-020-18991-8

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