Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases

The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly e...

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Detalles Bibliográficos
Autores principales: Herrmann, Sandra M., Alexander, Mariam P., Romero, Michael F., Zand, Ladan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568062/
https://www.ncbi.nlm.nih.gov/pubmed/33089143
http://dx.doi.org/10.1016/j.xkme.2020.05.015
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author Herrmann, Sandra M.
Alexander, Mariam P.
Romero, Michael F.
Zand, Ladan
author_facet Herrmann, Sandra M.
Alexander, Mariam P.
Romero, Michael F.
Zand, Ladan
author_sort Herrmann, Sandra M.
collection PubMed
description The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly electrolyte disorders secondary to renal tubular acidosis as an immune-related adverse event and discuss the potential mechanism. Nongap acidosis in combination with hypokalemia should raise suspicion for distal renal tubular acidosis in patients treated with ICIs.
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spelling pubmed-75680622020-10-20 Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases Herrmann, Sandra M. Alexander, Mariam P. Romero, Michael F. Zand, Ladan Kidney Med Case Report The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly electrolyte disorders secondary to renal tubular acidosis as an immune-related adverse event and discuss the potential mechanism. Nongap acidosis in combination with hypokalemia should raise suspicion for distal renal tubular acidosis in patients treated with ICIs. Elsevier 2020-08-11 /pmc/articles/PMC7568062/ /pubmed/33089143 http://dx.doi.org/10.1016/j.xkme.2020.05.015 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Herrmann, Sandra M.
Alexander, Mariam P.
Romero, Michael F.
Zand, Ladan
Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases
title Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases
title_full Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases
title_fullStr Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases
title_full_unstemmed Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases
title_short Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases
title_sort renal tubular acidosis and immune checkpoint inhibitor therapy: an immune-related adverse event of pd-1 inhibitor—a report of 3 cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568062/
https://www.ncbi.nlm.nih.gov/pubmed/33089143
http://dx.doi.org/10.1016/j.xkme.2020.05.015
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